Anti-podocalyxin antibody exerts antitumor effects via antibody-dependent cellular cytotoxicity in mouse xenograft models of oral squamous cell carcinoma

Podocalyxin (PODXL) overexpression is associated with progression, metastasis, and poor outcomes in cancers. We recently produced the novel anti-PODXL monoclonal antibody (mAb) PcMab-47 (IgG(1), kappa). Herein, we engineered PcMab-47 into 47-mG(2a), a mouse IgG(2a)-type mAb, to add antibody-dependen...

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Detalles Bibliográficos
Autores principales: Itai, Shunsuke, Ohishi, Tomokazu, Kaneko, Mika K., Yamada, Shinji, Abe, Shinji, Nakamura, Takuro, Yanaka, Miyuki, Chang, Yao-Wen, Ohba, Shun-Ichi, Nishioka, Yasuhiko, Kawada, Manabu, Harada, Hiroyuki, Kato, Yukinari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976479/
https://www.ncbi.nlm.nih.gov/pubmed/29854293
http://dx.doi.org/10.18632/oncotarget.25132

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976479/
https://www.ncbi.nlm.nih.gov/pubmed/29854293
http://dx.doi.org/10.18632/oncotarget.25132

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