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GPR43 mediates microbiota metabolite SCFA regulation of antimicrobial peptide expression in intestinal epithelial cells via activation of mTOR and STAT3

The antimicrobial peptides (AMP) produced by intestinal epithelial cells (IEC) play crucial roles in the regulation of intestinal homeostasis by controlling microbiota. Gut microbiota has been shown to promote IEC expression of RegIIIγ and certain defensins. However, the mechanisms involved are stil...

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Detalles Bibliográficos
Autores principales:	Zhao, Ye, Chen, Feidi, Wu, Wei, Sun, Mingming, Bilotta, Anthony J., Yao, Suxia, Xiao, Yi, Huang, Xiangsheng, Eaves-Pyles, Tonyia D., Golovko, George, Fofanov, Yuriy, D’Souza, Warren, Zhao, Qihong, Liu, Zhanju, Cong, Yingzi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976519/ https://www.ncbi.nlm.nih.gov/pubmed/29411774 http://dx.doi.org/10.1038/mi.2017.118

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