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Increase lipid tear thickness after botulinum neurotoxin A injection in patients with blepharospasm and hemifacial spasm

The aim of this study was to investigate changes in the tear film lipid layer thickness (LLT) and aqueous tear production after botulinum neurotoxin A (BoNT) injection in patients with benign essential blepharospasm (BEB) and hemifacial spasm (HFS). Eleven and six patients with BEB and HFS, respecti...

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Autores principales: Ho, Ren-Wen, Fang, Po-Chiung, Chao, Tsai-Ling, Chien, Chun-Chih, Kuo, Ming-Tse
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976660/
https://www.ncbi.nlm.nih.gov/pubmed/29849166
http://dx.doi.org/10.1038/s41598-018-26750-5
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author Ho, Ren-Wen
Fang, Po-Chiung
Chao, Tsai-Ling
Chien, Chun-Chih
Kuo, Ming-Tse
author_facet Ho, Ren-Wen
Fang, Po-Chiung
Chao, Tsai-Ling
Chien, Chun-Chih
Kuo, Ming-Tse
author_sort Ho, Ren-Wen
collection PubMed
description The aim of this study was to investigate changes in the tear film lipid layer thickness (LLT) and aqueous tear production after botulinum neurotoxin A (BoNT) injection in patients with benign essential blepharospasm (BEB) and hemifacial spasm (HFS). Eleven and six patients with BEB and HFS, respectively, who received BoNT injection were consecutively enrolled in this prospective study. The blepharospasm disability index (BSDI), blink pattern, dry eye symptoms, Schirmer test 1 findings, LLT, eyelid performance, and corneal integrity were evaluated before and after treatment. Both BEB and HSF patients experienced remarkable relief from spasms and ocular discomfort after BoNT injection. LLT, the partial blink rate, the snap-back time, the lid distraction distance, and lateral canthal laxity were significantly increased at 1 month after treatment. There were no significant changes in Schirmer test 1 findings and meibomian gland dropout. Our findings suggest that LLT, a decisive factor for tear film stability, significantly increases at 1 month after BoNT injection for BEB and HFS. A decrease in BSDI and an increase in the snap-back time may contribute to the increase in LLT; this mechanism is probably responsible for the relief from dryness after BoNT injection in patients with facial movement disorders.
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spelling pubmed-59766602018-05-31 Increase lipid tear thickness after botulinum neurotoxin A injection in patients with blepharospasm and hemifacial spasm Ho, Ren-Wen Fang, Po-Chiung Chao, Tsai-Ling Chien, Chun-Chih Kuo, Ming-Tse Sci Rep Article The aim of this study was to investigate changes in the tear film lipid layer thickness (LLT) and aqueous tear production after botulinum neurotoxin A (BoNT) injection in patients with benign essential blepharospasm (BEB) and hemifacial spasm (HFS). Eleven and six patients with BEB and HFS, respectively, who received BoNT injection were consecutively enrolled in this prospective study. The blepharospasm disability index (BSDI), blink pattern, dry eye symptoms, Schirmer test 1 findings, LLT, eyelid performance, and corneal integrity were evaluated before and after treatment. Both BEB and HSF patients experienced remarkable relief from spasms and ocular discomfort after BoNT injection. LLT, the partial blink rate, the snap-back time, the lid distraction distance, and lateral canthal laxity were significantly increased at 1 month after treatment. There were no significant changes in Schirmer test 1 findings and meibomian gland dropout. Our findings suggest that LLT, a decisive factor for tear film stability, significantly increases at 1 month after BoNT injection for BEB and HFS. A decrease in BSDI and an increase in the snap-back time may contribute to the increase in LLT; this mechanism is probably responsible for the relief from dryness after BoNT injection in patients with facial movement disorders. Nature Publishing Group UK 2018-05-30 /pmc/articles/PMC5976660/ /pubmed/29849166 http://dx.doi.org/10.1038/s41598-018-26750-5 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Ho, Ren-Wen
Fang, Po-Chiung
Chao, Tsai-Ling
Chien, Chun-Chih
Kuo, Ming-Tse
Increase lipid tear thickness after botulinum neurotoxin A injection in patients with blepharospasm and hemifacial spasm
title Increase lipid tear thickness after botulinum neurotoxin A injection in patients with blepharospasm and hemifacial spasm
title_full Increase lipid tear thickness after botulinum neurotoxin A injection in patients with blepharospasm and hemifacial spasm
title_fullStr Increase lipid tear thickness after botulinum neurotoxin A injection in patients with blepharospasm and hemifacial spasm
title_full_unstemmed Increase lipid tear thickness after botulinum neurotoxin A injection in patients with blepharospasm and hemifacial spasm
title_short Increase lipid tear thickness after botulinum neurotoxin A injection in patients with blepharospasm and hemifacial spasm
title_sort increase lipid tear thickness after botulinum neurotoxin a injection in patients with blepharospasm and hemifacial spasm
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976660/
https://www.ncbi.nlm.nih.gov/pubmed/29849166
http://dx.doi.org/10.1038/s41598-018-26750-5
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