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Birth weight variants are associated with variable fetal intrauterine growth from 20 weeks of gestation
Fetal intrauterine growth is influenced by complex interactions between the maternal genes, environment and fetal genes. The aim of this study was to assess the effect of GWAS-identified genetic variants associated with birth weight on intrauterine fetal growth in 665 children. Fetal growth was esti...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976727/ https://www.ncbi.nlm.nih.gov/pubmed/29849051 http://dx.doi.org/10.1038/s41598-018-26752-3 |
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author | Engelbrechtsen, L. Gybel-Brask, D. Mahendran, Y. Crusell, M. Hansen, T. H. Schnurr, T. M. Hogdall, E. Skibsted, L. Hansen, T. Vestergaard, H. |
author_facet | Engelbrechtsen, L. Gybel-Brask, D. Mahendran, Y. Crusell, M. Hansen, T. H. Schnurr, T. M. Hogdall, E. Skibsted, L. Hansen, T. Vestergaard, H. |
author_sort | Engelbrechtsen, L. |
collection | PubMed |
description | Fetal intrauterine growth is influenced by complex interactions between the maternal genes, environment and fetal genes. The aim of this study was to assess the effect of GWAS-identified genetic variants associated with birth weight on intrauterine fetal growth in 665 children. Fetal growth was estimated by two-dimensional ultrasound scans at 20, 25 and 32 weeks of gestation and growth trajectories were modeled using mixed linear regression. A genetic risk score (GRS) of birth weight-raising variants was associated with intrauterine growth showing an attenuating effect on the unconditional daily reduction in proportional weight gain of 8.92 × 10(−6) percentage points/allele/day (p = 2.0 × 10(−4)), corresponding to a mean difference of 410 g at 40 weeks of gestation between a child with lowest and highest GRS. Eight variants were independently associated with intrauterine growth throughout the pregnancy, while four variants were associated with fetal growth in the periods 20–25 or 25–32 weeks of gestation, indicating that some variants may act in specific time windows during pregnancy. Four of the intrauterine growth variants were associated with type 2 diabetes, hypertension or BMI in the UK Biobank, which may provide basis for further understanding of the link between intrauterine growth and later risk of metabolic disease. |
format | Online Article Text |
id | pubmed-5976727 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-59767272018-05-31 Birth weight variants are associated with variable fetal intrauterine growth from 20 weeks of gestation Engelbrechtsen, L. Gybel-Brask, D. Mahendran, Y. Crusell, M. Hansen, T. H. Schnurr, T. M. Hogdall, E. Skibsted, L. Hansen, T. Vestergaard, H. Sci Rep Article Fetal intrauterine growth is influenced by complex interactions between the maternal genes, environment and fetal genes. The aim of this study was to assess the effect of GWAS-identified genetic variants associated with birth weight on intrauterine fetal growth in 665 children. Fetal growth was estimated by two-dimensional ultrasound scans at 20, 25 and 32 weeks of gestation and growth trajectories were modeled using mixed linear regression. A genetic risk score (GRS) of birth weight-raising variants was associated with intrauterine growth showing an attenuating effect on the unconditional daily reduction in proportional weight gain of 8.92 × 10(−6) percentage points/allele/day (p = 2.0 × 10(−4)), corresponding to a mean difference of 410 g at 40 weeks of gestation between a child with lowest and highest GRS. Eight variants were independently associated with intrauterine growth throughout the pregnancy, while four variants were associated with fetal growth in the periods 20–25 or 25–32 weeks of gestation, indicating that some variants may act in specific time windows during pregnancy. Four of the intrauterine growth variants were associated with type 2 diabetes, hypertension or BMI in the UK Biobank, which may provide basis for further understanding of the link between intrauterine growth and later risk of metabolic disease. Nature Publishing Group UK 2018-05-30 /pmc/articles/PMC5976727/ /pubmed/29849051 http://dx.doi.org/10.1038/s41598-018-26752-3 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Engelbrechtsen, L. Gybel-Brask, D. Mahendran, Y. Crusell, M. Hansen, T. H. Schnurr, T. M. Hogdall, E. Skibsted, L. Hansen, T. Vestergaard, H. Birth weight variants are associated with variable fetal intrauterine growth from 20 weeks of gestation |
title | Birth weight variants are associated with variable fetal intrauterine growth from 20 weeks of gestation |
title_full | Birth weight variants are associated with variable fetal intrauterine growth from 20 weeks of gestation |
title_fullStr | Birth weight variants are associated with variable fetal intrauterine growth from 20 weeks of gestation |
title_full_unstemmed | Birth weight variants are associated with variable fetal intrauterine growth from 20 weeks of gestation |
title_short | Birth weight variants are associated with variable fetal intrauterine growth from 20 weeks of gestation |
title_sort | birth weight variants are associated with variable fetal intrauterine growth from 20 weeks of gestation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976727/ https://www.ncbi.nlm.nih.gov/pubmed/29849051 http://dx.doi.org/10.1038/s41598-018-26752-3 |
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