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Urinary Markers of Oxidative Stress Are Associated With Albuminuria But Not GFR Decline

INTRODUCTION: Markers of oxidative stress increase with age and are prevalent with chronic kidney disease. However, the role of oxidative stress markers as predictors for kidney function decline in the general population is unclear. METHODS: We investigated whether a baseline urinary excretion of ox...

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Autores principales: Schei, Jørgen, Fuskevåg, Ole-Martin, Stefansson, Vidar Tor Nyborg, Solbu, Marit Dahl, Jenssen, Trond Geir, Eriksen, Bjørn Odvar, Melsom, Toralf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976868/
https://www.ncbi.nlm.nih.gov/pubmed/29854964
http://dx.doi.org/10.1016/j.ekir.2017.11.020
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author Schei, Jørgen
Fuskevåg, Ole-Martin
Stefansson, Vidar Tor Nyborg
Solbu, Marit Dahl
Jenssen, Trond Geir
Eriksen, Bjørn Odvar
Melsom, Toralf
author_facet Schei, Jørgen
Fuskevåg, Ole-Martin
Stefansson, Vidar Tor Nyborg
Solbu, Marit Dahl
Jenssen, Trond Geir
Eriksen, Bjørn Odvar
Melsom, Toralf
author_sort Schei, Jørgen
collection PubMed
description INTRODUCTION: Markers of oxidative stress increase with age and are prevalent with chronic kidney disease. However, the role of oxidative stress markers as predictors for kidney function decline in the general population is unclear. METHODS: We investigated whether a baseline urinary excretion of oxidative DNA damage (8-oxo-7,8-dihydro-2′-deoxyguanosine [8-oxodG]) and oxidative RNA damage (8-oxo-7,8-dihydroguanosine [8-oxoGuo]) was associated with the age-related glomerular filtration rate (GFR) decline or incident low-grade albuminuria during a median of 5.6 years of follow-up. In the Renal Iohexol Clearance Survey in the Sixth Tromsø Study, we measured GFR using iohexol clearance in 1591 participants without renal disease, diabetes, or cardiovascular disease. Low-grade albuminuria was defined as an albumin-creatinine ratio >1.13 mg/mmol. RESULTS: The mean (SD) annual GFR change was −0.84 (2.00) ml/min per 1.73 m(2) per year. In linear mixed models, urinary 8-oxodG and 8-oxoGuo levels were not associated with the GFR change rate. In a multivariable adjusted logistic regression model, a baseline urinary 8-oxoGuo in the highest quartile was associated with an increased risk of low-grade albuminuria at follow-up (odds ratio: 2.64; 95% confidence interval: 1.50–4.65). When the highest quartile of urinary 8-oxoGuo was added to the baseline model, the area under the receiver operating characteristics curve for predicting low-grade albuminuria at follow-up improved from 0.67 to 0.71 (P = 0.002). CONCLUSION: Oxidative stress measured as urinary 8-oxoGuo excretion was independently associated with incident low-grade albuminuria, but neither 8-oxoGuo nor 8-oxodG predicted an accelerated age-related GFR decline in a cohort representative of the middle-aged general population during almost 6 years of follow-up.
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spelling pubmed-59768682018-05-31 Urinary Markers of Oxidative Stress Are Associated With Albuminuria But Not GFR Decline Schei, Jørgen Fuskevåg, Ole-Martin Stefansson, Vidar Tor Nyborg Solbu, Marit Dahl Jenssen, Trond Geir Eriksen, Bjørn Odvar Melsom, Toralf Kidney Int Rep Clinical Research INTRODUCTION: Markers of oxidative stress increase with age and are prevalent with chronic kidney disease. However, the role of oxidative stress markers as predictors for kidney function decline in the general population is unclear. METHODS: We investigated whether a baseline urinary excretion of oxidative DNA damage (8-oxo-7,8-dihydro-2′-deoxyguanosine [8-oxodG]) and oxidative RNA damage (8-oxo-7,8-dihydroguanosine [8-oxoGuo]) was associated with the age-related glomerular filtration rate (GFR) decline or incident low-grade albuminuria during a median of 5.6 years of follow-up. In the Renal Iohexol Clearance Survey in the Sixth Tromsø Study, we measured GFR using iohexol clearance in 1591 participants without renal disease, diabetes, or cardiovascular disease. Low-grade albuminuria was defined as an albumin-creatinine ratio >1.13 mg/mmol. RESULTS: The mean (SD) annual GFR change was −0.84 (2.00) ml/min per 1.73 m(2) per year. In linear mixed models, urinary 8-oxodG and 8-oxoGuo levels were not associated with the GFR change rate. In a multivariable adjusted logistic regression model, a baseline urinary 8-oxoGuo in the highest quartile was associated with an increased risk of low-grade albuminuria at follow-up (odds ratio: 2.64; 95% confidence interval: 1.50–4.65). When the highest quartile of urinary 8-oxoGuo was added to the baseline model, the area under the receiver operating characteristics curve for predicting low-grade albuminuria at follow-up improved from 0.67 to 0.71 (P = 0.002). CONCLUSION: Oxidative stress measured as urinary 8-oxoGuo excretion was independently associated with incident low-grade albuminuria, but neither 8-oxoGuo nor 8-oxodG predicted an accelerated age-related GFR decline in a cohort representative of the middle-aged general population during almost 6 years of follow-up. Elsevier 2017-12-07 /pmc/articles/PMC5976868/ /pubmed/29854964 http://dx.doi.org/10.1016/j.ekir.2017.11.020 Text en © 2017 International Society of Nephrology. Published by Elsevier Inc. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Clinical Research
Schei, Jørgen
Fuskevåg, Ole-Martin
Stefansson, Vidar Tor Nyborg
Solbu, Marit Dahl
Jenssen, Trond Geir
Eriksen, Bjørn Odvar
Melsom, Toralf
Urinary Markers of Oxidative Stress Are Associated With Albuminuria But Not GFR Decline
title Urinary Markers of Oxidative Stress Are Associated With Albuminuria But Not GFR Decline
title_full Urinary Markers of Oxidative Stress Are Associated With Albuminuria But Not GFR Decline
title_fullStr Urinary Markers of Oxidative Stress Are Associated With Albuminuria But Not GFR Decline
title_full_unstemmed Urinary Markers of Oxidative Stress Are Associated With Albuminuria But Not GFR Decline
title_short Urinary Markers of Oxidative Stress Are Associated With Albuminuria But Not GFR Decline
title_sort urinary markers of oxidative stress are associated with albuminuria but not gfr decline
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976868/
https://www.ncbi.nlm.nih.gov/pubmed/29854964
http://dx.doi.org/10.1016/j.ekir.2017.11.020
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