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Effects of 5-Hydroxymethylcytosine Epigenetic Modification on the Stability and Molecular Recognition of VEGF i-Motif and G-Quadruplex Structures

Promoters often contain asymmetric G- and C-rich strands, in which the cytosines are prone to epigenetic modification via methylation (5-mC) and 5-hydroxymethylation (5-hmC). These sequences can also form four-stranded G-quadruplex (G4) or i-motif (iM) secondary structures. Although the requisite se...

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Detalles Bibliográficos
Autores principales:	Morgan, Rhianna K., Molnar, Michael M., Batra, Harshul, Summerford, Bethany, Wadkins, Randy M., Brooks, Tracy A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976936/ https://www.ncbi.nlm.nih.gov/pubmed/29862069 http://dx.doi.org/10.1155/2018/9281286

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