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MicroRNA-219-5p Promotes Tumor Growth and Metastasis of Hepatocellular Carcinoma by Regulating Cadherin 1

MicroRNAs play significant roles in the development of cancer and may serve as promising therapeutic targets. In our previous work, miR-219-5p was identified as one of the important metastasis-related microRNAs in HCC. Here we demonstrated that miR-219-5p expression was elevated in HCC tissues and w...

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Autores principales: Yang, Jing, Sheng, Yuan-Yuan, Wei, Jin-Wang, Gao, Xiao-Mei, Zhu, Ying, Jia, Hu-Liang, Dong, Qiong-Zhu, Qin, Lun-Xiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976989/
https://www.ncbi.nlm.nih.gov/pubmed/29862272
http://dx.doi.org/10.1155/2018/4793971
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author Yang, Jing
Sheng, Yuan-Yuan
Wei, Jin-Wang
Gao, Xiao-Mei
Zhu, Ying
Jia, Hu-Liang
Dong, Qiong-Zhu
Qin, Lun-Xiu
author_facet Yang, Jing
Sheng, Yuan-Yuan
Wei, Jin-Wang
Gao, Xiao-Mei
Zhu, Ying
Jia, Hu-Liang
Dong, Qiong-Zhu
Qin, Lun-Xiu
author_sort Yang, Jing
collection PubMed
description MicroRNAs play significant roles in the development of cancer and may serve as promising therapeutic targets. In our previous work, miR-219-5p was identified as one of the important metastasis-related microRNAs in HCC. Here we demonstrated that miR-219-5p expression was elevated in HCC tissues and was associated with vascular invasion and dismal prognosis. In multivariate analysis, miR-219-5p was identified as an independent prognostic indicator for HCC patients. Functional mechanism analyses showed that miR-219-5p promoted HCC cell proliferation and invasion in in vitro, as well as in vivo, tumor growth and metastasis in nude mice models bearing human HCC tumors. In addition, cadherin 1 (CDH1) was revealed to be a downstream target of miR-219-5p in HCC cells. In conclusion, miR-219-5p promotes tumor growth and metastasis of HCC by regulating CDH1 and can serve as a prognostic marker for HCC patients.
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spelling pubmed-59769892018-06-03 MicroRNA-219-5p Promotes Tumor Growth and Metastasis of Hepatocellular Carcinoma by Regulating Cadherin 1 Yang, Jing Sheng, Yuan-Yuan Wei, Jin-Wang Gao, Xiao-Mei Zhu, Ying Jia, Hu-Liang Dong, Qiong-Zhu Qin, Lun-Xiu Biomed Res Int Research Article MicroRNAs play significant roles in the development of cancer and may serve as promising therapeutic targets. In our previous work, miR-219-5p was identified as one of the important metastasis-related microRNAs in HCC. Here we demonstrated that miR-219-5p expression was elevated in HCC tissues and was associated with vascular invasion and dismal prognosis. In multivariate analysis, miR-219-5p was identified as an independent prognostic indicator for HCC patients. Functional mechanism analyses showed that miR-219-5p promoted HCC cell proliferation and invasion in in vitro, as well as in vivo, tumor growth and metastasis in nude mice models bearing human HCC tumors. In addition, cadherin 1 (CDH1) was revealed to be a downstream target of miR-219-5p in HCC cells. In conclusion, miR-219-5p promotes tumor growth and metastasis of HCC by regulating CDH1 and can serve as a prognostic marker for HCC patients. Hindawi 2018-05-15 /pmc/articles/PMC5976989/ /pubmed/29862272 http://dx.doi.org/10.1155/2018/4793971 Text en Copyright © 2018 Jing Yang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Yang, Jing
Sheng, Yuan-Yuan
Wei, Jin-Wang
Gao, Xiao-Mei
Zhu, Ying
Jia, Hu-Liang
Dong, Qiong-Zhu
Qin, Lun-Xiu
MicroRNA-219-5p Promotes Tumor Growth and Metastasis of Hepatocellular Carcinoma by Regulating Cadherin 1
title MicroRNA-219-5p Promotes Tumor Growth and Metastasis of Hepatocellular Carcinoma by Regulating Cadherin 1
title_full MicroRNA-219-5p Promotes Tumor Growth and Metastasis of Hepatocellular Carcinoma by Regulating Cadherin 1
title_fullStr MicroRNA-219-5p Promotes Tumor Growth and Metastasis of Hepatocellular Carcinoma by Regulating Cadherin 1
title_full_unstemmed MicroRNA-219-5p Promotes Tumor Growth and Metastasis of Hepatocellular Carcinoma by Regulating Cadherin 1
title_short MicroRNA-219-5p Promotes Tumor Growth and Metastasis of Hepatocellular Carcinoma by Regulating Cadherin 1
title_sort microrna-219-5p promotes tumor growth and metastasis of hepatocellular carcinoma by regulating cadherin 1
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976989/
https://www.ncbi.nlm.nih.gov/pubmed/29862272
http://dx.doi.org/10.1155/2018/4793971
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