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Hearing Loss in Adult Survivors of Childhood Cancer Treated with Radiotherapy

The ototoxic effects of radiotherapy have been poorly characterized. We examined adult survivors of childhood cancer who were treated with radiotherapy, which included the head, before the age of 22 years and between 1952 and 2016. Those who received platinum chemotherapy were excluded. Demographic,...

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Autores principales: Khan, Amber, Budnick, Amy, Barnea, Dana, Feldman, Darren R., Oeffinger, Kevin C., Tonorezos, Emily S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977041/
https://www.ncbi.nlm.nih.gov/pubmed/29734694
http://dx.doi.org/10.3390/children5050059
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author Khan, Amber
Budnick, Amy
Barnea, Dana
Feldman, Darren R.
Oeffinger, Kevin C.
Tonorezos, Emily S.
author_facet Khan, Amber
Budnick, Amy
Barnea, Dana
Feldman, Darren R.
Oeffinger, Kevin C.
Tonorezos, Emily S.
author_sort Khan, Amber
collection PubMed
description The ototoxic effects of radiotherapy have been poorly characterized. We examined adult survivors of childhood cancer who were treated with radiotherapy, which included the head, before the age of 22 years and between 1952 and 2016. Those who received platinum chemotherapy were excluded. Demographic, diagnosis, and treatment outcomes were captured. Audiograms were graded using the Chang and International Society of Paediatric Oncology ototoxicity (SIOP) scales. Among 276 patients with a history of radiation to sites that included the brain, orbit, nasopharynx, and total body irradiation, the median age at treatment was 10.1 years and 59% were male. Of 51 survivors who had post-treatment audiograms, 19 demonstrated severe hearing impairment according to both the Chang and SIOP scales after a median follow-up of 16.6 years. Of those with severe impairment, 10 were using hearing aids. Among the 23 patients with more than one audiogram, five had normal hearing on the first audiogram but hearing loss upon subsequent study. Ototoxic effects of radiotherapy are present in a significant portion of survivors, but impairment may present over time, and our results suggest that many are not being screened. Further, among patients with severe hearing loss, use of hearing aids is not universal. Expansion of access to audiology testing and hearing interventions may be warranted.
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spelling pubmed-59770412018-05-31 Hearing Loss in Adult Survivors of Childhood Cancer Treated with Radiotherapy Khan, Amber Budnick, Amy Barnea, Dana Feldman, Darren R. Oeffinger, Kevin C. Tonorezos, Emily S. Children (Basel) Article The ototoxic effects of radiotherapy have been poorly characterized. We examined adult survivors of childhood cancer who were treated with radiotherapy, which included the head, before the age of 22 years and between 1952 and 2016. Those who received platinum chemotherapy were excluded. Demographic, diagnosis, and treatment outcomes were captured. Audiograms were graded using the Chang and International Society of Paediatric Oncology ototoxicity (SIOP) scales. Among 276 patients with a history of radiation to sites that included the brain, orbit, nasopharynx, and total body irradiation, the median age at treatment was 10.1 years and 59% were male. Of 51 survivors who had post-treatment audiograms, 19 demonstrated severe hearing impairment according to both the Chang and SIOP scales after a median follow-up of 16.6 years. Of those with severe impairment, 10 were using hearing aids. Among the 23 patients with more than one audiogram, five had normal hearing on the first audiogram but hearing loss upon subsequent study. Ototoxic effects of radiotherapy are present in a significant portion of survivors, but impairment may present over time, and our results suggest that many are not being screened. Further, among patients with severe hearing loss, use of hearing aids is not universal. Expansion of access to audiology testing and hearing interventions may be warranted. MDPI 2018-05-04 /pmc/articles/PMC5977041/ /pubmed/29734694 http://dx.doi.org/10.3390/children5050059 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Khan, Amber
Budnick, Amy
Barnea, Dana
Feldman, Darren R.
Oeffinger, Kevin C.
Tonorezos, Emily S.
Hearing Loss in Adult Survivors of Childhood Cancer Treated with Radiotherapy
title Hearing Loss in Adult Survivors of Childhood Cancer Treated with Radiotherapy
title_full Hearing Loss in Adult Survivors of Childhood Cancer Treated with Radiotherapy
title_fullStr Hearing Loss in Adult Survivors of Childhood Cancer Treated with Radiotherapy
title_full_unstemmed Hearing Loss in Adult Survivors of Childhood Cancer Treated with Radiotherapy
title_short Hearing Loss in Adult Survivors of Childhood Cancer Treated with Radiotherapy
title_sort hearing loss in adult survivors of childhood cancer treated with radiotherapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977041/
https://www.ncbi.nlm.nih.gov/pubmed/29734694
http://dx.doi.org/10.3390/children5050059
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