Toward the Discovery of a Novel Class of YAP–TEAD Interaction Inhibitors by Virtual Screening Approach Targeting YAP–TEAD Protein–Protein Interface

Intrinsically disordered protein YAP (yes-associated protein) interacts with TEADs transcriptional factors family (transcriptional enhancer associated domain) creating three interfaces. Interface 3, between the Ω-loop of YAP and a shallow pocket of TEAD was identified as the most important TEAD zone...

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Detalles Bibliográficos
Autores principales: Gibault, Floriane, Coevoet, Mathilde, Sturbaut, Manon, Farce, Amaury, Renault, Nicolas, Allemand, Frédéric, Guichou, Jean-François, Drucbert, Anne-Sophie, Foulon, Catherine, Magnez, Romain, Thuru, Xavier, Corvaisier, Matthieu, Huet, Guillemette, Chavatte, Philippe, Melnyk, Patricia, Bailly, Fabrice, Cotelle, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977113/
https://www.ncbi.nlm.nih.gov/pubmed/29738494
http://dx.doi.org/10.3390/cancers10050140

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977113/
https://www.ncbi.nlm.nih.gov/pubmed/29738494
http://dx.doi.org/10.3390/cancers10050140

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