p53-Autophagy-Metastasis Link

The tumor suppressor p53 as the “guardian of the genome” plays an essential role in numerous signaling pathways that control the cell cycle, cell death and in maintaining the integrity of the human genome. p53, depending on the intracellular localization, contributes to the regulation of various cel...

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Detalles Bibliográficos
Autores principales: Denisenko, Tatiana V., Pivnyuk, Anastasia D., Zhivotovsky, Boris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977121/
https://www.ncbi.nlm.nih.gov/pubmed/29783720
http://dx.doi.org/10.3390/cancers10050148
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author Denisenko, Tatiana V.
Pivnyuk, Anastasia D.
Zhivotovsky, Boris
author_facet Denisenko, Tatiana V.
Pivnyuk, Anastasia D.
Zhivotovsky, Boris
author_sort Denisenko, Tatiana V.
collection PubMed
description The tumor suppressor p53 as the “guardian of the genome” plays an essential role in numerous signaling pathways that control the cell cycle, cell death and in maintaining the integrity of the human genome. p53, depending on the intracellular localization, contributes to the regulation of various cell death pathways, including apoptosis, autophagy and necroptosis. Accumulated evidence suggests that this function of p53 is closely involved in the process of cancer development. Here, present knowledge concerning a p53-autophagy-metastasis link, as well as therapeutic approaches that influence this link, are discussed.
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spelling pubmed-59771212018-05-31 p53-Autophagy-Metastasis Link Denisenko, Tatiana V. Pivnyuk, Anastasia D. Zhivotovsky, Boris Cancers (Basel) Review The tumor suppressor p53 as the “guardian of the genome” plays an essential role in numerous signaling pathways that control the cell cycle, cell death and in maintaining the integrity of the human genome. p53, depending on the intracellular localization, contributes to the regulation of various cell death pathways, including apoptosis, autophagy and necroptosis. Accumulated evidence suggests that this function of p53 is closely involved in the process of cancer development. Here, present knowledge concerning a p53-autophagy-metastasis link, as well as therapeutic approaches that influence this link, are discussed. MDPI 2018-05-18 /pmc/articles/PMC5977121/ /pubmed/29783720 http://dx.doi.org/10.3390/cancers10050148 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Denisenko, Tatiana V.
Pivnyuk, Anastasia D.
Zhivotovsky, Boris
p53-Autophagy-Metastasis Link
title p53-Autophagy-Metastasis Link
title_full p53-Autophagy-Metastasis Link
title_fullStr p53-Autophagy-Metastasis Link
title_full_unstemmed p53-Autophagy-Metastasis Link
title_short p53-Autophagy-Metastasis Link
title_sort p53-autophagy-metastasis link
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977121/
https://www.ncbi.nlm.nih.gov/pubmed/29783720
http://dx.doi.org/10.3390/cancers10050148
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