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Multimodal Assessment of Recurrent MTBI across the Lifespan

Recurrent mild traumatic brain injuries (mTBI) and its neurological sequelae have been the focus of a large number of studies, indicating cognitive, structural, and functional brain alterations. However, studies often focused on single outcome measures in small cohorts of specific populations only....

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Autores principales: Wilke, Skadi, Prehn, Kristin, Taud, Benedikt, List, Jonathan, Flöel, Agnes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977134/
https://www.ncbi.nlm.nih.gov/pubmed/29723976
http://dx.doi.org/10.3390/jcm7050095
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author Wilke, Skadi
Prehn, Kristin
Taud, Benedikt
List, Jonathan
Flöel, Agnes
author_facet Wilke, Skadi
Prehn, Kristin
Taud, Benedikt
List, Jonathan
Flöel, Agnes
author_sort Wilke, Skadi
collection PubMed
description Recurrent mild traumatic brain injuries (mTBI) and its neurological sequelae have been the focus of a large number of studies, indicating cognitive, structural, and functional brain alterations. However, studies often focused on single outcome measures in small cohorts of specific populations only. We conducted a multimodal evaluation of the impact of recurrent mTBI on a broad range of cognitive functions, regional brain volume, white matter integrity, and resting state functional connectivity (RSFC) in young and older adults in the chronic stage (>6 months after the last mTBI). Seventeen young participants with mTBI (age: 24.2 ± 2.8 (mean ± SD)) and 21 group-wise matched healthy controls (age: 25.8 ± 5.4 (mean ± SD)), as well as 17 older participants with mTBI (age: 62.7 ± 7.7 (mean ± SD)) and 16 group-wise matched healthy controls (age: 61.7 ± 5.9 (mean ± SD)) were evaluated. We found significant differences in the verbal fluency between young participants with mTBI and young healthy controls. Furthermore, differences in the regional volume of precuneus and medial orbitofrontal gyrus between participants with mTBI and controls for both age groups were seen. A significant age by group interaction for the right hippocampal volume was noted, indicating an accelerated hippocampal volume loss in older participants with mTBI. Other cognitive parameters, white matter integrity, and RSFC showed no significant differences. We confirmed some of the previously reported detrimental effects of recurrent mTBI, but also demonstrated inconspicuous findings for the majority of parameters.
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spelling pubmed-59771342018-05-31 Multimodal Assessment of Recurrent MTBI across the Lifespan Wilke, Skadi Prehn, Kristin Taud, Benedikt List, Jonathan Flöel, Agnes J Clin Med Article Recurrent mild traumatic brain injuries (mTBI) and its neurological sequelae have been the focus of a large number of studies, indicating cognitive, structural, and functional brain alterations. However, studies often focused on single outcome measures in small cohorts of specific populations only. We conducted a multimodal evaluation of the impact of recurrent mTBI on a broad range of cognitive functions, regional brain volume, white matter integrity, and resting state functional connectivity (RSFC) in young and older adults in the chronic stage (>6 months after the last mTBI). Seventeen young participants with mTBI (age: 24.2 ± 2.8 (mean ± SD)) and 21 group-wise matched healthy controls (age: 25.8 ± 5.4 (mean ± SD)), as well as 17 older participants with mTBI (age: 62.7 ± 7.7 (mean ± SD)) and 16 group-wise matched healthy controls (age: 61.7 ± 5.9 (mean ± SD)) were evaluated. We found significant differences in the verbal fluency between young participants with mTBI and young healthy controls. Furthermore, differences in the regional volume of precuneus and medial orbitofrontal gyrus between participants with mTBI and controls for both age groups were seen. A significant age by group interaction for the right hippocampal volume was noted, indicating an accelerated hippocampal volume loss in older participants with mTBI. Other cognitive parameters, white matter integrity, and RSFC showed no significant differences. We confirmed some of the previously reported detrimental effects of recurrent mTBI, but also demonstrated inconspicuous findings for the majority of parameters. MDPI 2018-05-01 /pmc/articles/PMC5977134/ /pubmed/29723976 http://dx.doi.org/10.3390/jcm7050095 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wilke, Skadi
Prehn, Kristin
Taud, Benedikt
List, Jonathan
Flöel, Agnes
Multimodal Assessment of Recurrent MTBI across the Lifespan
title Multimodal Assessment of Recurrent MTBI across the Lifespan
title_full Multimodal Assessment of Recurrent MTBI across the Lifespan
title_fullStr Multimodal Assessment of Recurrent MTBI across the Lifespan
title_full_unstemmed Multimodal Assessment of Recurrent MTBI across the Lifespan
title_short Multimodal Assessment of Recurrent MTBI across the Lifespan
title_sort multimodal assessment of recurrent mtbi across the lifespan
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977134/
https://www.ncbi.nlm.nih.gov/pubmed/29723976
http://dx.doi.org/10.3390/jcm7050095
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