Cargando…
Long-Term Statin Administration Does Not Affect Warfarin Time in Therapeutic Range in Australia or Singapore
Background: Warfarin requires ongoing monitoring of the International Normalised Ratio (INR). This is because numerous factors influence the response, including drug interactions with commonly-prescribed medications, such as statins. The administration of statins with warfarin may change INR; howeve...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977136/ https://www.ncbi.nlm.nih.gov/pubmed/29723987 http://dx.doi.org/10.3390/jcm7050097 |
_version_ | 1783327313080877056 |
---|---|
author | Bernaitis, Nijole Ching, Chi Keong Teo, Siew Chong Badrick, Tony Davey, Andrew K. Crilly, Julia Anoopkumar-Dukie, Shailendra |
author_facet | Bernaitis, Nijole Ching, Chi Keong Teo, Siew Chong Badrick, Tony Davey, Andrew K. Crilly, Julia Anoopkumar-Dukie, Shailendra |
author_sort | Bernaitis, Nijole |
collection | PubMed |
description | Background: Warfarin requires ongoing monitoring of the International Normalised Ratio (INR). This is because numerous factors influence the response, including drug interactions with commonly-prescribed medications, such as statins. The administration of statins with warfarin may change INR; however, there is limited information regarding the effects on warfarin control as measured by time in therapeutic range (TTR). Statins may also alter bleeds with warfarin, but there are conflicting reports demonstrating both increased and decreased bleeds, and limited data on diverse ethnic populations. Therefore, the aim of this study was to determine the effect of statin administration on warfarin control and bleeds in patients in Australia and Singapore. Methods: Retrospective data were collected for patients on warfarin between January and June 2014 in Australia and Singapore. Patient data were used to calculate TTR and bleed events. Concurrent statin therapy was assessed and comparisons of TTR and bleed incidence were made across patient subgroups. Results: Warfarin control in Australia and Singapore was not significantly affected by statins, as measured by TTR (83% and 58%, respectively), frequency of testing, and warfarin doses. In Australia, statin use did not significantly affect bleeds, whilst in Singapore the bleed incidence was significantly lower for patients on statins. Conclusions: Chronic concurrent administration of statins with warfarin does not adversely affect warfarin TTR in Australia or Singapore. In Singapore, patients on statins, compared to no statins, had a lower bleed incidence and this requires further investigation, especially given the potential genetic influences of ethnicity on both statin and warfarin metabolism. |
format | Online Article Text |
id | pubmed-5977136 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-59771362018-05-31 Long-Term Statin Administration Does Not Affect Warfarin Time in Therapeutic Range in Australia or Singapore Bernaitis, Nijole Ching, Chi Keong Teo, Siew Chong Badrick, Tony Davey, Andrew K. Crilly, Julia Anoopkumar-Dukie, Shailendra J Clin Med Article Background: Warfarin requires ongoing monitoring of the International Normalised Ratio (INR). This is because numerous factors influence the response, including drug interactions with commonly-prescribed medications, such as statins. The administration of statins with warfarin may change INR; however, there is limited information regarding the effects on warfarin control as measured by time in therapeutic range (TTR). Statins may also alter bleeds with warfarin, but there are conflicting reports demonstrating both increased and decreased bleeds, and limited data on diverse ethnic populations. Therefore, the aim of this study was to determine the effect of statin administration on warfarin control and bleeds in patients in Australia and Singapore. Methods: Retrospective data were collected for patients on warfarin between January and June 2014 in Australia and Singapore. Patient data were used to calculate TTR and bleed events. Concurrent statin therapy was assessed and comparisons of TTR and bleed incidence were made across patient subgroups. Results: Warfarin control in Australia and Singapore was not significantly affected by statins, as measured by TTR (83% and 58%, respectively), frequency of testing, and warfarin doses. In Australia, statin use did not significantly affect bleeds, whilst in Singapore the bleed incidence was significantly lower for patients on statins. Conclusions: Chronic concurrent administration of statins with warfarin does not adversely affect warfarin TTR in Australia or Singapore. In Singapore, patients on statins, compared to no statins, had a lower bleed incidence and this requires further investigation, especially given the potential genetic influences of ethnicity on both statin and warfarin metabolism. MDPI 2018-05-01 /pmc/articles/PMC5977136/ /pubmed/29723987 http://dx.doi.org/10.3390/jcm7050097 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Bernaitis, Nijole Ching, Chi Keong Teo, Siew Chong Badrick, Tony Davey, Andrew K. Crilly, Julia Anoopkumar-Dukie, Shailendra Long-Term Statin Administration Does Not Affect Warfarin Time in Therapeutic Range in Australia or Singapore |
title | Long-Term Statin Administration Does Not Affect Warfarin Time in Therapeutic Range in Australia or Singapore |
title_full | Long-Term Statin Administration Does Not Affect Warfarin Time in Therapeutic Range in Australia or Singapore |
title_fullStr | Long-Term Statin Administration Does Not Affect Warfarin Time in Therapeutic Range in Australia or Singapore |
title_full_unstemmed | Long-Term Statin Administration Does Not Affect Warfarin Time in Therapeutic Range in Australia or Singapore |
title_short | Long-Term Statin Administration Does Not Affect Warfarin Time in Therapeutic Range in Australia or Singapore |
title_sort | long-term statin administration does not affect warfarin time in therapeutic range in australia or singapore |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977136/ https://www.ncbi.nlm.nih.gov/pubmed/29723987 http://dx.doi.org/10.3390/jcm7050097 |
work_keys_str_mv | AT bernaitisnijole longtermstatinadministrationdoesnotaffectwarfarintimeintherapeuticrangeinaustraliaorsingapore AT chingchikeong longtermstatinadministrationdoesnotaffectwarfarintimeintherapeuticrangeinaustraliaorsingapore AT teosiewchong longtermstatinadministrationdoesnotaffectwarfarintimeintherapeuticrangeinaustraliaorsingapore AT badricktony longtermstatinadministrationdoesnotaffectwarfarintimeintherapeuticrangeinaustraliaorsingapore AT daveyandrewk longtermstatinadministrationdoesnotaffectwarfarintimeintherapeuticrangeinaustraliaorsingapore AT crillyjulia longtermstatinadministrationdoesnotaffectwarfarintimeintherapeuticrangeinaustraliaorsingapore AT anoopkumardukieshailendra longtermstatinadministrationdoesnotaffectwarfarintimeintherapeuticrangeinaustraliaorsingapore |