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The Gender Impact on Morphogenetic Variability in Coronary Artery Disease: A Preliminary Study

We analyzed morphogenetic variability and degree of genetic homozygosity in male and female individuals with coronary artery disease (CAD) versus unaffected controls. We have tested 235 CAD patients; 109 were diagnosed also with diabetes mellitus (DM) and 126 with hypertension (HTN). We additionally...

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Autores principales: Karan, Radmila, Obrenovic-Kircanski, Biljana, Cvjeticanin, Suzana, Kovacevic-Kostic, Natasa, Velinovic, Milos, Milicevic, Vladimir, Vranes-Stoimirov, Milica, Nikolic, Dejan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977142/
https://www.ncbi.nlm.nih.gov/pubmed/29751567
http://dx.doi.org/10.3390/jcm7050103
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author Karan, Radmila
Obrenovic-Kircanski, Biljana
Cvjeticanin, Suzana
Kovacevic-Kostic, Natasa
Velinovic, Milos
Milicevic, Vladimir
Vranes-Stoimirov, Milica
Nikolic, Dejan
author_facet Karan, Radmila
Obrenovic-Kircanski, Biljana
Cvjeticanin, Suzana
Kovacevic-Kostic, Natasa
Velinovic, Milos
Milicevic, Vladimir
Vranes-Stoimirov, Milica
Nikolic, Dejan
author_sort Karan, Radmila
collection PubMed
description We analyzed morphogenetic variability and degree of genetic homozygosity in male and female individuals with coronary artery disease (CAD) versus unaffected controls. We have tested 235 CAD patients; 109 were diagnosed also with diabetes mellitus (DM) and 126 with hypertension (HTN). We additionally evaluated 152 healthy individuals without manifested CAD. For the evaluation of the degree of recessive homozygosity, we have performed the homozygously recessive characteristics (HRC) test and tested 19 HRCs. In controls, the frequency of HRC for males was 2.88 ± 1.89, while for females, it was 3.65 ± 1.60. In the CAD group, the frequency of HRC for males was 4.21 ± 1.47, while for females, it was 4.73 ± 1.60. There is significant difference in HRC frequencies between controls and CAD separately for males (p < 0.001) and females (p < 0.001). The same applies between controls and CAD with DM (males: p < 0.001 and females: p = 0.004), and controls and CAD with HTN (males: p < 0.001 and females: p < 0.001). There is no significant difference in HRC frequencies between the group of CAD with DM and the group of CAD with HTN (males: p = 0.952 and females: p = 0.529). Our findings point to the increased degree of recessive homozygosity and decreased variability in both genders of CAD patients versus controls, indicating the potential genetic predisposition for CAD.
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spelling pubmed-59771422018-05-31 The Gender Impact on Morphogenetic Variability in Coronary Artery Disease: A Preliminary Study Karan, Radmila Obrenovic-Kircanski, Biljana Cvjeticanin, Suzana Kovacevic-Kostic, Natasa Velinovic, Milos Milicevic, Vladimir Vranes-Stoimirov, Milica Nikolic, Dejan J Clin Med Article We analyzed morphogenetic variability and degree of genetic homozygosity in male and female individuals with coronary artery disease (CAD) versus unaffected controls. We have tested 235 CAD patients; 109 were diagnosed also with diabetes mellitus (DM) and 126 with hypertension (HTN). We additionally evaluated 152 healthy individuals without manifested CAD. For the evaluation of the degree of recessive homozygosity, we have performed the homozygously recessive characteristics (HRC) test and tested 19 HRCs. In controls, the frequency of HRC for males was 2.88 ± 1.89, while for females, it was 3.65 ± 1.60. In the CAD group, the frequency of HRC for males was 4.21 ± 1.47, while for females, it was 4.73 ± 1.60. There is significant difference in HRC frequencies between controls and CAD separately for males (p < 0.001) and females (p < 0.001). The same applies between controls and CAD with DM (males: p < 0.001 and females: p = 0.004), and controls and CAD with HTN (males: p < 0.001 and females: p < 0.001). There is no significant difference in HRC frequencies between the group of CAD with DM and the group of CAD with HTN (males: p = 0.952 and females: p = 0.529). Our findings point to the increased degree of recessive homozygosity and decreased variability in both genders of CAD patients versus controls, indicating the potential genetic predisposition for CAD. MDPI 2018-05-03 /pmc/articles/PMC5977142/ /pubmed/29751567 http://dx.doi.org/10.3390/jcm7050103 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Karan, Radmila
Obrenovic-Kircanski, Biljana
Cvjeticanin, Suzana
Kovacevic-Kostic, Natasa
Velinovic, Milos
Milicevic, Vladimir
Vranes-Stoimirov, Milica
Nikolic, Dejan
The Gender Impact on Morphogenetic Variability in Coronary Artery Disease: A Preliminary Study
title The Gender Impact on Morphogenetic Variability in Coronary Artery Disease: A Preliminary Study
title_full The Gender Impact on Morphogenetic Variability in Coronary Artery Disease: A Preliminary Study
title_fullStr The Gender Impact on Morphogenetic Variability in Coronary Artery Disease: A Preliminary Study
title_full_unstemmed The Gender Impact on Morphogenetic Variability in Coronary Artery Disease: A Preliminary Study
title_short The Gender Impact on Morphogenetic Variability in Coronary Artery Disease: A Preliminary Study
title_sort gender impact on morphogenetic variability in coronary artery disease: a preliminary study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977142/
https://www.ncbi.nlm.nih.gov/pubmed/29751567
http://dx.doi.org/10.3390/jcm7050103
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