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Practice Trends of Fibrinogen Monitoring in Thrombolysis
There is a lack of evidence or societal guidelines regarding the utility of fibrinogen monitoring during thrombolysis. The purpose of our study was to investigate the current use of monitoring fibrinogen levels during thrombolysis. A voluntary, anonymous online survey was sent to all physician membe...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977150/ https://www.ncbi.nlm.nih.gov/pubmed/29748480 http://dx.doi.org/10.3390/jcm7050111 |
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author | Kaufman, Claire Kinney, Thomas Quencer, Keith |
author_facet | Kaufman, Claire Kinney, Thomas Quencer, Keith |
author_sort | Kaufman, Claire |
collection | PubMed |
description | There is a lack of evidence or societal guidelines regarding the utility of fibrinogen monitoring during thrombolysis. The purpose of our study was to investigate the current use of monitoring fibrinogen levels during thrombolysis. A voluntary, anonymous online survey was sent to all physician members of the Society of Interventional Radiology, consisting of 23 questions related to practitioner demographics, thrombolysis protocol, and fibrinogen monitoring. There were 455 physician responses; 82% of respondents monitored fibrinogen levels during thrombolysis, of which 97% decreased or stopped tissue plasminogen activator based on the level. Self-reported estimates of significant bleeding events during thrombolysis were 1.86% in those who monitored fibrinogen and 1.93% in those who did not. Only 34% of all respondents report, in their clinical experience, having found low fibrinogen level to be correlated with bleeding events. There was no significant difference in self-reported major bleeding rates between practitioners who monitor and those who do not monitor fibrinogen. This high variability of clinical use of fibrinogen monitoring during catheter-directed thrombolysis is secondary to the paucity of scientific studies demonstrating its utility; further scientific investigation is needed to define the true utility of fibrinogen monitoring. |
format | Online Article Text |
id | pubmed-5977150 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-59771502018-05-31 Practice Trends of Fibrinogen Monitoring in Thrombolysis Kaufman, Claire Kinney, Thomas Quencer, Keith J Clin Med Article There is a lack of evidence or societal guidelines regarding the utility of fibrinogen monitoring during thrombolysis. The purpose of our study was to investigate the current use of monitoring fibrinogen levels during thrombolysis. A voluntary, anonymous online survey was sent to all physician members of the Society of Interventional Radiology, consisting of 23 questions related to practitioner demographics, thrombolysis protocol, and fibrinogen monitoring. There were 455 physician responses; 82% of respondents monitored fibrinogen levels during thrombolysis, of which 97% decreased or stopped tissue plasminogen activator based on the level. Self-reported estimates of significant bleeding events during thrombolysis were 1.86% in those who monitored fibrinogen and 1.93% in those who did not. Only 34% of all respondents report, in their clinical experience, having found low fibrinogen level to be correlated with bleeding events. There was no significant difference in self-reported major bleeding rates between practitioners who monitor and those who do not monitor fibrinogen. This high variability of clinical use of fibrinogen monitoring during catheter-directed thrombolysis is secondary to the paucity of scientific studies demonstrating its utility; further scientific investigation is needed to define the true utility of fibrinogen monitoring. MDPI 2018-05-10 /pmc/articles/PMC5977150/ /pubmed/29748480 http://dx.doi.org/10.3390/jcm7050111 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kaufman, Claire Kinney, Thomas Quencer, Keith Practice Trends of Fibrinogen Monitoring in Thrombolysis |
title | Practice Trends of Fibrinogen Monitoring in Thrombolysis |
title_full | Practice Trends of Fibrinogen Monitoring in Thrombolysis |
title_fullStr | Practice Trends of Fibrinogen Monitoring in Thrombolysis |
title_full_unstemmed | Practice Trends of Fibrinogen Monitoring in Thrombolysis |
title_short | Practice Trends of Fibrinogen Monitoring in Thrombolysis |
title_sort | practice trends of fibrinogen monitoring in thrombolysis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977150/ https://www.ncbi.nlm.nih.gov/pubmed/29748480 http://dx.doi.org/10.3390/jcm7050111 |
work_keys_str_mv | AT kaufmanclaire practicetrendsoffibrinogenmonitoringinthrombolysis AT kinneythomas practicetrendsoffibrinogenmonitoringinthrombolysis AT quencerkeith practicetrendsoffibrinogenmonitoringinthrombolysis |