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Association of Cardiovascular Health with Epicardial Adipose Tissue and Intima Media Thickness: The Kardiovize Study

Background: Intima-media thickness (IMT) has been proposed as a measurement of subclinical atherosclerosis and has been associated with cardiovascular disease (CVD). Epicardial adipose tissue (EAT) is a fat depot between the pericardium and myocardium and has been associated with coronary atheroscle...

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Autores principales: Hruskova, Jana, Maugeri, Andrea, Podroužková, Helena, Štípalová, Tatiana, Jakubík, Juraj, Barchitta, Martina, Medina-Inojosa, Jose R., Homolka, Martin, Agodi, Antonella, Kunzova, Sarka, Sochor, Ondrej, Lopez-Jimenez, Francisco, Vinciguerra, Manlio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977152/
https://www.ncbi.nlm.nih.gov/pubmed/29757253
http://dx.doi.org/10.3390/jcm7050113
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author Hruskova, Jana
Maugeri, Andrea
Podroužková, Helena
Štípalová, Tatiana
Jakubík, Juraj
Barchitta, Martina
Medina-Inojosa, Jose R.
Homolka, Martin
Agodi, Antonella
Kunzova, Sarka
Sochor, Ondrej
Lopez-Jimenez, Francisco
Vinciguerra, Manlio
author_facet Hruskova, Jana
Maugeri, Andrea
Podroužková, Helena
Štípalová, Tatiana
Jakubík, Juraj
Barchitta, Martina
Medina-Inojosa, Jose R.
Homolka, Martin
Agodi, Antonella
Kunzova, Sarka
Sochor, Ondrej
Lopez-Jimenez, Francisco
Vinciguerra, Manlio
author_sort Hruskova, Jana
collection PubMed
description Background: Intima-media thickness (IMT) has been proposed as a measurement of subclinical atherosclerosis and has been associated with cardiovascular disease (CVD). Epicardial adipose tissue (EAT) is a fat depot between the pericardium and myocardium and has been associated with coronary atherosclerosis. The relationship between IMT and EAT thickness has not been reported before. We investigated the relationship between EAT thickness, IMT, CVD risk factors, and ideal cardiovascular health (CVH) metrics using subjects from the Kardiovize Brno 2030 cohort study, a random urban sample population in Central Europe. Methods: We studied 102 individuals (65 males) aged 25–64 years (median = 37 years) with no current or past CVD history. We measured IMT using a vascular ultrasound and EAT thickness using transthoracic echocardiography, and collected data on anthropometric factors, CVD risk factors, and CVH score. Correlation tests and multiple linear regression models were applied. Results: In the age- and gender-adjusted model, we demonstrated that, among CVD risk factors, only BMI was significantly and positively associated with EAT thickness (β = 0.182, SE = 0.082, p = 0.030), while no significant associations with IMT were evident. Although both EAT thickness and IMT were negatively correlated with CVH score (r = −0.45, p < 0.001, and r = −0.38, p < 0.001, respectively), we demonstrated that overall CVH score (β = −0.262; SE = 0.077; p = 0.001), as well as BMI (β = −1.305; SE = 0.194; p < 0.001) and blood pressure CVH metrics (β = −0.607; SE = 0.206; p = 0.004) were significantly associated with EAT thickness but not with IMT. Conclusions: Our study is important as it demonstrated for the first time that CVH is associated with EAT thickness. Interestingly, this relationship seems to be dependent on BMI and blood pressure rather than on the other CVH metrics. However, outcome-driven studies are required to confirm these findings.
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spelling pubmed-59771522018-05-31 Association of Cardiovascular Health with Epicardial Adipose Tissue and Intima Media Thickness: The Kardiovize Study Hruskova, Jana Maugeri, Andrea Podroužková, Helena Štípalová, Tatiana Jakubík, Juraj Barchitta, Martina Medina-Inojosa, Jose R. Homolka, Martin Agodi, Antonella Kunzova, Sarka Sochor, Ondrej Lopez-Jimenez, Francisco Vinciguerra, Manlio J Clin Med Article Background: Intima-media thickness (IMT) has been proposed as a measurement of subclinical atherosclerosis and has been associated with cardiovascular disease (CVD). Epicardial adipose tissue (EAT) is a fat depot between the pericardium and myocardium and has been associated with coronary atherosclerosis. The relationship between IMT and EAT thickness has not been reported before. We investigated the relationship between EAT thickness, IMT, CVD risk factors, and ideal cardiovascular health (CVH) metrics using subjects from the Kardiovize Brno 2030 cohort study, a random urban sample population in Central Europe. Methods: We studied 102 individuals (65 males) aged 25–64 years (median = 37 years) with no current or past CVD history. We measured IMT using a vascular ultrasound and EAT thickness using transthoracic echocardiography, and collected data on anthropometric factors, CVD risk factors, and CVH score. Correlation tests and multiple linear regression models were applied. Results: In the age- and gender-adjusted model, we demonstrated that, among CVD risk factors, only BMI was significantly and positively associated with EAT thickness (β = 0.182, SE = 0.082, p = 0.030), while no significant associations with IMT were evident. Although both EAT thickness and IMT were negatively correlated with CVH score (r = −0.45, p < 0.001, and r = −0.38, p < 0.001, respectively), we demonstrated that overall CVH score (β = −0.262; SE = 0.077; p = 0.001), as well as BMI (β = −1.305; SE = 0.194; p < 0.001) and blood pressure CVH metrics (β = −0.607; SE = 0.206; p = 0.004) were significantly associated with EAT thickness but not with IMT. Conclusions: Our study is important as it demonstrated for the first time that CVH is associated with EAT thickness. Interestingly, this relationship seems to be dependent on BMI and blood pressure rather than on the other CVH metrics. However, outcome-driven studies are required to confirm these findings. MDPI 2018-05-13 /pmc/articles/PMC5977152/ /pubmed/29757253 http://dx.doi.org/10.3390/jcm7050113 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hruskova, Jana
Maugeri, Andrea
Podroužková, Helena
Štípalová, Tatiana
Jakubík, Juraj
Barchitta, Martina
Medina-Inojosa, Jose R.
Homolka, Martin
Agodi, Antonella
Kunzova, Sarka
Sochor, Ondrej
Lopez-Jimenez, Francisco
Vinciguerra, Manlio
Association of Cardiovascular Health with Epicardial Adipose Tissue and Intima Media Thickness: The Kardiovize Study
title Association of Cardiovascular Health with Epicardial Adipose Tissue and Intima Media Thickness: The Kardiovize Study
title_full Association of Cardiovascular Health with Epicardial Adipose Tissue and Intima Media Thickness: The Kardiovize Study
title_fullStr Association of Cardiovascular Health with Epicardial Adipose Tissue and Intima Media Thickness: The Kardiovize Study
title_full_unstemmed Association of Cardiovascular Health with Epicardial Adipose Tissue and Intima Media Thickness: The Kardiovize Study
title_short Association of Cardiovascular Health with Epicardial Adipose Tissue and Intima Media Thickness: The Kardiovize Study
title_sort association of cardiovascular health with epicardial adipose tissue and intima media thickness: the kardiovize study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977152/
https://www.ncbi.nlm.nih.gov/pubmed/29757253
http://dx.doi.org/10.3390/jcm7050113
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