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Genetic Mechanisms of Asthma and the Implications for Drug Repositioning

Asthma is a chronic disease that is caused by airway inflammation. The main features of asthma are airway hyperresponsiveness (AHR) and reversible airway obstruction. The disease is mainly managed using drug therapy. The current asthma drug treatments are divided into two categories, namely, anti-in...

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Detalles Bibliográficos
Autores principales: Huo, Yue, Zhang, Hong-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977177/
https://www.ncbi.nlm.nih.gov/pubmed/29751569
http://dx.doi.org/10.3390/genes9050237
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author Huo, Yue
Zhang, Hong-Yu
author_facet Huo, Yue
Zhang, Hong-Yu
author_sort Huo, Yue
collection PubMed
description Asthma is a chronic disease that is caused by airway inflammation. The main features of asthma are airway hyperresponsiveness (AHR) and reversible airway obstruction. The disease is mainly managed using drug therapy. The current asthma drug treatments are divided into two categories, namely, anti-inflammatory drugs and bronchodilators. However, disease control in asthma patients is not very efficient because the pathogenesis of asthma is complicated, inducing factors that are varied, such as the differences between individual patients. In this paper, we delineate the genetic mechanisms of asthma, and present asthma-susceptible genes and genetic pharmacology in an attempt to find a diagnosis, early prevention, and treatment methods for asthma. Finally, we reposition some clinical drugs for asthma therapy, based on asthma genetics.
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spelling pubmed-59771772018-05-31 Genetic Mechanisms of Asthma and the Implications for Drug Repositioning Huo, Yue Zhang, Hong-Yu Genes (Basel) Review Asthma is a chronic disease that is caused by airway inflammation. The main features of asthma are airway hyperresponsiveness (AHR) and reversible airway obstruction. The disease is mainly managed using drug therapy. The current asthma drug treatments are divided into two categories, namely, anti-inflammatory drugs and bronchodilators. However, disease control in asthma patients is not very efficient because the pathogenesis of asthma is complicated, inducing factors that are varied, such as the differences between individual patients. In this paper, we delineate the genetic mechanisms of asthma, and present asthma-susceptible genes and genetic pharmacology in an attempt to find a diagnosis, early prevention, and treatment methods for asthma. Finally, we reposition some clinical drugs for asthma therapy, based on asthma genetics. MDPI 2018-05-03 /pmc/articles/PMC5977177/ /pubmed/29751569 http://dx.doi.org/10.3390/genes9050237 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Huo, Yue
Zhang, Hong-Yu
Genetic Mechanisms of Asthma and the Implications for Drug Repositioning
title Genetic Mechanisms of Asthma and the Implications for Drug Repositioning
title_full Genetic Mechanisms of Asthma and the Implications for Drug Repositioning
title_fullStr Genetic Mechanisms of Asthma and the Implications for Drug Repositioning
title_full_unstemmed Genetic Mechanisms of Asthma and the Implications for Drug Repositioning
title_short Genetic Mechanisms of Asthma and the Implications for Drug Repositioning
title_sort genetic mechanisms of asthma and the implications for drug repositioning
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977177/
https://www.ncbi.nlm.nih.gov/pubmed/29751569
http://dx.doi.org/10.3390/genes9050237
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