Comparative Pathogenesis of Asian and African-Lineage Zika Virus in Indian Rhesus Macaque’s and Development of a Non-Human Primate Model Suitable for the Evaluation of New Drugs and Vaccines

The establishment of a well characterized non-human primate model of Zika virus (ZIKV) infection is critical for the development of medical interventions. In this study, challenging Indian rhesus macaques (IRMs) with ZIKV strains of the Asian lineage resulted in dose-dependent peak viral loads betwe...

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Detalles Bibliográficos
Autores principales: Rayner, Jonathan O., Kalkeri, Raj, Goebel, Scott, Cai, Zhaohui, Green, Brian, Lin, Shuling, Snyder, Beth, Hagelin, Kimberly, Walters, Kevin B., Koide, Fusataka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977222/
https://www.ncbi.nlm.nih.gov/pubmed/29723973
http://dx.doi.org/10.3390/v10050229

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