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Characterization of an N-Terminal Non-Core Domain of RAG1 Gene Disrupted Syrian Hamster Model Generated by CRISPR Cas9

The accumulating evidence demonstrates that Syrian hamsters have advantages as models for various diseases. To develop a Syrian hamster (Mesocricetus auratus) model of human immunodeficiency caused by RAG1 gene mutations, we employed the CRISPR/Cas9 system and introduced an 86-nucleotide frameshift...

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Detalles Bibliográficos
Autores principales:	Miao, Jinxin, Ying, Baoling, Li, Rong, Tollefson, Ann E., Spencer, Jacqueline F., Wold, William S. M., Song, Seok-Hwan, Kong, Il-Keun, Toth, Karoly, Wang, Yaohe, Wang, Zhongde
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977236/ https://www.ncbi.nlm.nih.gov/pubmed/29734775 http://dx.doi.org/10.3390/v10050243

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