Adaptive Mutations in Influenza A/California/07/2009 Enhance Polymerase Activity and Infectious Virion Production

Mice are not natural hosts for influenza A viruses (IAVs), but they are useful models for studying antiviral immune responses and pathogenesis. Serial passage of IAV in mice invariably causes the emergence of adaptive mutations and increased virulence. Here, we report the adaptation of IAV reference...

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Detalles Bibliográficos
Autores principales: Slaine, Patrick D., MacRae, Cara, Kleer, Mariel, Lamoureux, Emily, McAlpine, Sarah, Warhuus, Michelle, Comeau, André M., McCormick, Craig, Hatchette, Todd, Khaperskyy, Denys A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977265/
https://www.ncbi.nlm.nih.gov/pubmed/29783694
http://dx.doi.org/10.3390/v10050272

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977265/
https://www.ncbi.nlm.nih.gov/pubmed/29783694
http://dx.doi.org/10.3390/v10050272

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