BRAF inhibition with concomitant tumor treating fields for a multiply progressive pleomorphic xanthoastrocytoma

Pleomorphic xanthoastrocytomas can be very resistant to treatment if they progress after standard therapy with surgery and radiation. We present the case of a patient with a multiply recurrent pleomorphic xanthoastrocytoma which demonstrated a sustained partial response to a combination regimen of t...

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Detalles Bibliográficos
Autores principales: Lukas, Rimas V, Merrell, Ryan T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Medicine Ltd 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977279/
https://www.ncbi.nlm.nih.gov/pubmed/29708404
http://dx.doi.org/10.2217/cns-2017-0032
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author Lukas, Rimas V
Merrell, Ryan T
author_facet Lukas, Rimas V
Merrell, Ryan T
author_sort Lukas, Rimas V
collection PubMed
description Pleomorphic xanthoastrocytomas can be very resistant to treatment if they progress after standard therapy with surgery and radiation. We present the case of a patient with a multiply recurrent pleomorphic xanthoastrocytoma which demonstrated a sustained partial response to a combination regimen of the BRAF inhibitor vemurafenib and tumor treating fields. The regimen proved tolerable and efficacious in this case.
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spelling pubmed-59772792018-06-04 BRAF inhibition with concomitant tumor treating fields for a multiply progressive pleomorphic xanthoastrocytoma Lukas, Rimas V Merrell, Ryan T CNS Oncol Case Report Pleomorphic xanthoastrocytomas can be very resistant to treatment if they progress after standard therapy with surgery and radiation. We present the case of a patient with a multiply recurrent pleomorphic xanthoastrocytoma which demonstrated a sustained partial response to a combination regimen of the BRAF inhibitor vemurafenib and tumor treating fields. The regimen proved tolerable and efficacious in this case. Future Medicine Ltd 2018-04-30 /pmc/articles/PMC5977279/ /pubmed/29708404 http://dx.doi.org/10.2217/cns-2017-0032 Text en © 2018 Rimas Lukas & Ryan Merrell This work is licensed under a Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/)
spellingShingle Case Report
Lukas, Rimas V
Merrell, Ryan T
BRAF inhibition with concomitant tumor treating fields for a multiply progressive pleomorphic xanthoastrocytoma
title BRAF inhibition with concomitant tumor treating fields for a multiply progressive pleomorphic xanthoastrocytoma
title_full BRAF inhibition with concomitant tumor treating fields for a multiply progressive pleomorphic xanthoastrocytoma
title_fullStr BRAF inhibition with concomitant tumor treating fields for a multiply progressive pleomorphic xanthoastrocytoma
title_full_unstemmed BRAF inhibition with concomitant tumor treating fields for a multiply progressive pleomorphic xanthoastrocytoma
title_short BRAF inhibition with concomitant tumor treating fields for a multiply progressive pleomorphic xanthoastrocytoma
title_sort braf inhibition with concomitant tumor treating fields for a multiply progressive pleomorphic xanthoastrocytoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977279/
https://www.ncbi.nlm.nih.gov/pubmed/29708404
http://dx.doi.org/10.2217/cns-2017-0032
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