Engineering a 3D-Bioprinted Model of Human Heart Valve Disease Using Nanoindentation-Based Biomechanics

In calcific aortic valve disease (CAVD), microcalcifications originating from nanoscale calcifying vesicles disrupt the aortic valve (AV) leaflets, which consist of three (biomechanically) distinct layers: the fibrosa, spongiosa, and ventricularis. CAVD has no pharmacotherapy and lacks in vitro mode...

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Detalles Bibliográficos
Autores principales: van der Valk, Dewy C., van der Ven, Casper F. T., Blaser, Mark C., Grolman, Joshua M., Wu, Pin-Jou, Fenton, Owen S., Lee, Lang H., Tibbitt, Mark W., Andresen, Jason L., Wen, Jennifer R., Ha, Anna H., Buffolo, Fabrizio, van Mil, Alain, Bouten, Carlijn V. C., Body, Simon C., Mooney, David J., Sluijter, Joost P. G., Aikawa, Masanori, Hjortnaes, Jesper, Langer, Robert, Aikawa, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977310/
https://www.ncbi.nlm.nih.gov/pubmed/29751516
http://dx.doi.org/10.3390/nano8050296

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