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Synthesis of Iron Oxide/Gold Composite Nanoparticles Using Polyethyleneimine as a Polymeric Active Stabilizer for Development of a Dual Imaging Probe

The combination of magnetic and plasmonic properties using iron oxide/gold nanocomposite particles is crucial for the development of multimodal molecular imaging probes. In this study, iron oxide/gold composite nanoparticles (NanoIOGs) were synthesized via the on-site reduction of an Au precursor sa...

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Autores principales: Yoon, Gyu Jin, Lee, So Young, Lee, Seung Bin, Park, Ga Young, Choi, Jin Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977314/
https://www.ncbi.nlm.nih.gov/pubmed/29734725
http://dx.doi.org/10.3390/nano8050300
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author Yoon, Gyu Jin
Lee, So Young
Lee, Seung Bin
Park, Ga Young
Choi, Jin Hyun
author_facet Yoon, Gyu Jin
Lee, So Young
Lee, Seung Bin
Park, Ga Young
Choi, Jin Hyun
author_sort Yoon, Gyu Jin
collection PubMed
description The combination of magnetic and plasmonic properties using iron oxide/gold nanocomposite particles is crucial for the development of multimodal molecular imaging probes. In this study, iron oxide/gold composite nanoparticles (NanoIOGs) were synthesized via the on-site reduction of an Au precursor salt by polyethyleneimine (PEI) molecules attached to iron oxide nanoparticles (IONPs), and they were employed in magnetic resonance and dark-field microscope imaging. PEI is considered as a polymeric active stabilizer (PAS), acting as a reducing agent for the synthesis of Au and a dispersant for nanoparticles. When the IONPs prepared at the PEI concentration of 0.02 wt. % were used for the NanoIOG synthesis, Au nanoseeds were formed around the IONPs. The alloy clusters of IONPs/Au crystals were produced with further reduction depending on PEI concentration. The NanoIOGs exhibited superparamagnetism in a magnetic field and plasmonic response in a dark-field (DF) microscope. The sizes, morphologies, magnetizations, and r(2) relaxivities of NanoIOGs were affected significantly by the amount of PEI added during the NanoIOG synthesis. It is suggested that the PAS-mediated synthesis is simple and effective, and can be applied to various nanostructured Au-metal alloys.
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spelling pubmed-59773142018-06-05 Synthesis of Iron Oxide/Gold Composite Nanoparticles Using Polyethyleneimine as a Polymeric Active Stabilizer for Development of a Dual Imaging Probe Yoon, Gyu Jin Lee, So Young Lee, Seung Bin Park, Ga Young Choi, Jin Hyun Nanomaterials (Basel) Article The combination of magnetic and plasmonic properties using iron oxide/gold nanocomposite particles is crucial for the development of multimodal molecular imaging probes. In this study, iron oxide/gold composite nanoparticles (NanoIOGs) were synthesized via the on-site reduction of an Au precursor salt by polyethyleneimine (PEI) molecules attached to iron oxide nanoparticles (IONPs), and they were employed in magnetic resonance and dark-field microscope imaging. PEI is considered as a polymeric active stabilizer (PAS), acting as a reducing agent for the synthesis of Au and a dispersant for nanoparticles. When the IONPs prepared at the PEI concentration of 0.02 wt. % were used for the NanoIOG synthesis, Au nanoseeds were formed around the IONPs. The alloy clusters of IONPs/Au crystals were produced with further reduction depending on PEI concentration. The NanoIOGs exhibited superparamagnetism in a magnetic field and plasmonic response in a dark-field (DF) microscope. The sizes, morphologies, magnetizations, and r(2) relaxivities of NanoIOGs were affected significantly by the amount of PEI added during the NanoIOG synthesis. It is suggested that the PAS-mediated synthesis is simple and effective, and can be applied to various nanostructured Au-metal alloys. MDPI 2018-05-05 /pmc/articles/PMC5977314/ /pubmed/29734725 http://dx.doi.org/10.3390/nano8050300 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yoon, Gyu Jin
Lee, So Young
Lee, Seung Bin
Park, Ga Young
Choi, Jin Hyun
Synthesis of Iron Oxide/Gold Composite Nanoparticles Using Polyethyleneimine as a Polymeric Active Stabilizer for Development of a Dual Imaging Probe
title Synthesis of Iron Oxide/Gold Composite Nanoparticles Using Polyethyleneimine as a Polymeric Active Stabilizer for Development of a Dual Imaging Probe
title_full Synthesis of Iron Oxide/Gold Composite Nanoparticles Using Polyethyleneimine as a Polymeric Active Stabilizer for Development of a Dual Imaging Probe
title_fullStr Synthesis of Iron Oxide/Gold Composite Nanoparticles Using Polyethyleneimine as a Polymeric Active Stabilizer for Development of a Dual Imaging Probe
title_full_unstemmed Synthesis of Iron Oxide/Gold Composite Nanoparticles Using Polyethyleneimine as a Polymeric Active Stabilizer for Development of a Dual Imaging Probe
title_short Synthesis of Iron Oxide/Gold Composite Nanoparticles Using Polyethyleneimine as a Polymeric Active Stabilizer for Development of a Dual Imaging Probe
title_sort synthesis of iron oxide/gold composite nanoparticles using polyethyleneimine as a polymeric active stabilizer for development of a dual imaging probe
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977314/
https://www.ncbi.nlm.nih.gov/pubmed/29734725
http://dx.doi.org/10.3390/nano8050300
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