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Silver Nanoparticles: Synthetic Routes, In Vitro Toxicity and Theranostic Applications for Cancer Disease
The large use of nanomaterials in many fields of application and commercial products highlights their potential toxicity on living organisms and the environment, despite their physico-chemical properties. Among these, silver nanoparticles (Ag NPs) are involved in biomedical applications such as anti...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977333/ https://www.ncbi.nlm.nih.gov/pubmed/29748469 http://dx.doi.org/10.3390/nano8050319 |
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author | De Matteis, Valeria Cascione, Mariafrancesca Toma, Chiara Cristina Leporatti, Stefano |
author_facet | De Matteis, Valeria Cascione, Mariafrancesca Toma, Chiara Cristina Leporatti, Stefano |
author_sort | De Matteis, Valeria |
collection | PubMed |
description | The large use of nanomaterials in many fields of application and commercial products highlights their potential toxicity on living organisms and the environment, despite their physico-chemical properties. Among these, silver nanoparticles (Ag NPs) are involved in biomedical applications such as antibacterial agents, drug delivery vectors and theranostics agents. In this review, we explain the common synthesis routes of Ag NPs using physical, chemical, and biological methods, following their toxicity mechanism in cells. In particular, we analyzed the physiological cellular pathway perturbations in terms of oxidative stress induction, mitochondrial membrane potential alteration, cell death, apoptosis, DNA damage and cytokines secretion after Ag NPs exposure. In addition, their potential anti-cancer activity and theranostic applications are discussed. |
format | Online Article Text |
id | pubmed-5977333 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-59773332018-06-05 Silver Nanoparticles: Synthetic Routes, In Vitro Toxicity and Theranostic Applications for Cancer Disease De Matteis, Valeria Cascione, Mariafrancesca Toma, Chiara Cristina Leporatti, Stefano Nanomaterials (Basel) Review The large use of nanomaterials in many fields of application and commercial products highlights their potential toxicity on living organisms and the environment, despite their physico-chemical properties. Among these, silver nanoparticles (Ag NPs) are involved in biomedical applications such as antibacterial agents, drug delivery vectors and theranostics agents. In this review, we explain the common synthesis routes of Ag NPs using physical, chemical, and biological methods, following their toxicity mechanism in cells. In particular, we analyzed the physiological cellular pathway perturbations in terms of oxidative stress induction, mitochondrial membrane potential alteration, cell death, apoptosis, DNA damage and cytokines secretion after Ag NPs exposure. In addition, their potential anti-cancer activity and theranostic applications are discussed. MDPI 2018-05-10 /pmc/articles/PMC5977333/ /pubmed/29748469 http://dx.doi.org/10.3390/nano8050319 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review De Matteis, Valeria Cascione, Mariafrancesca Toma, Chiara Cristina Leporatti, Stefano Silver Nanoparticles: Synthetic Routes, In Vitro Toxicity and Theranostic Applications for Cancer Disease |
title | Silver Nanoparticles: Synthetic Routes, In Vitro Toxicity and Theranostic Applications for Cancer Disease |
title_full | Silver Nanoparticles: Synthetic Routes, In Vitro Toxicity and Theranostic Applications for Cancer Disease |
title_fullStr | Silver Nanoparticles: Synthetic Routes, In Vitro Toxicity and Theranostic Applications for Cancer Disease |
title_full_unstemmed | Silver Nanoparticles: Synthetic Routes, In Vitro Toxicity and Theranostic Applications for Cancer Disease |
title_short | Silver Nanoparticles: Synthetic Routes, In Vitro Toxicity and Theranostic Applications for Cancer Disease |
title_sort | silver nanoparticles: synthetic routes, in vitro toxicity and theranostic applications for cancer disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977333/ https://www.ncbi.nlm.nih.gov/pubmed/29748469 http://dx.doi.org/10.3390/nano8050319 |
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