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Isoform-specific deletion of PKM2 constrains tumor initiation in a mouse model of soft tissue sarcoma

BACKGROUND: Alternative splicing of the Pkm gene product generates the PKM1 and PKM2 isoforms of the glycolytic enzyme pyruvate kinase. PKM2 expression is associated with embryogenesis, tissue regeneration, and cancer. PKM2 is also the pyruvate kinase isoform expressed in most wild-type adult tissue...

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Detalles Bibliográficos
Autores principales:	Dayton, Talya L., Gocheva, Vasilena, Miller, Kathryn M., Bhutkar, Arjun, Lewis, Caroline A., Bronson, Roderick T., Vander Heiden, Matthew G., Jacks, Tyler
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977456/ https://www.ncbi.nlm.nih.gov/pubmed/29854399 http://dx.doi.org/10.1186/s40170-018-0179-2

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