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An update on the Society for Immunotherapy of Cancer consensus statement on tumor immunotherapy for the treatment of cutaneous melanoma: version 2.0

BACKGROUND: Cancer immunotherapy has been firmly established as a standard of care for patients with advanced and metastatic melanoma. Therapeutic outcomes in clinical trials have resulted in the approval of 11 new drugs and/or combination regimens for patients with melanoma. However, prospective da...

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Autores principales: Sullivan, Ryan J., Atkins, Michael B., Kirkwood, John M., Agarwala, Sanjiv S., Clark, Joseph I., Ernstoff, Marc S., Fecher, Leslie, Gajewski, Thomas F., Gastman, Brian, Lawson, David H., Lutzky, Jose, McDermott, David F., Margolin, Kim A., Mehnert, Janice M., Pavlick, Anna C., Richards, Jon M., Rubin, Krista M., Sharfman, William, Silverstein, Steven, Slingluff, Craig L., Sondak, Vernon K., Tarhini, Ahmad A., Thompson, John A., Urba, Walter J., White, Richard L., Whitman, Eric D., Hodi, F. Stephen, Kaufman, Howard L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977556/
https://www.ncbi.nlm.nih.gov/pubmed/29848375
http://dx.doi.org/10.1186/s40425-018-0362-6
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author Sullivan, Ryan J.
Atkins, Michael B.
Kirkwood, John M.
Agarwala, Sanjiv S.
Clark, Joseph I.
Ernstoff, Marc S.
Fecher, Leslie
Gajewski, Thomas F.
Gastman, Brian
Lawson, David H.
Lutzky, Jose
McDermott, David F.
Margolin, Kim A.
Mehnert, Janice M.
Pavlick, Anna C.
Richards, Jon M.
Rubin, Krista M.
Sharfman, William
Silverstein, Steven
Slingluff, Craig L.
Sondak, Vernon K.
Tarhini, Ahmad A.
Thompson, John A.
Urba, Walter J.
White, Richard L.
Whitman, Eric D.
Hodi, F. Stephen
Kaufman, Howard L.
author_facet Sullivan, Ryan J.
Atkins, Michael B.
Kirkwood, John M.
Agarwala, Sanjiv S.
Clark, Joseph I.
Ernstoff, Marc S.
Fecher, Leslie
Gajewski, Thomas F.
Gastman, Brian
Lawson, David H.
Lutzky, Jose
McDermott, David F.
Margolin, Kim A.
Mehnert, Janice M.
Pavlick, Anna C.
Richards, Jon M.
Rubin, Krista M.
Sharfman, William
Silverstein, Steven
Slingluff, Craig L.
Sondak, Vernon K.
Tarhini, Ahmad A.
Thompson, John A.
Urba, Walter J.
White, Richard L.
Whitman, Eric D.
Hodi, F. Stephen
Kaufman, Howard L.
author_sort Sullivan, Ryan J.
collection PubMed
description BACKGROUND: Cancer immunotherapy has been firmly established as a standard of care for patients with advanced and metastatic melanoma. Therapeutic outcomes in clinical trials have resulted in the approval of 11 new drugs and/or combination regimens for patients with melanoma. However, prospective data to support evidence-based clinical decisions with respect to the optimal schedule and sequencing of immunotherapy and targeted agents, how best to manage emerging toxicities and when to stop treatment are not yet available. METHODS: To address this knowledge gap, the Society for Immunotherapy of Cancer (SITC) Melanoma Task Force developed a process for consensus recommendations for physicians treating patients with melanoma integrating evidence-based data, where available, with best expert consensus opinion. The initial consensus statement was published in 2013, and version 2.0 of this report is an update based on a recent meeting of the Task Force and extensive subsequent discussions on new agents, contemporary peer-reviewed literature and emerging clinical data. The Academy of Medicine (formerly Institute of Medicine) clinical practice guidelines were used as a basis for consensus development with an updated literature search for important studies published between 1992 and 2017 and supplemented, as appropriate, by recommendations from Task Force participants. RESULTS: The Task Force considered patients with stage II-IV melanoma and here provide consensus recommendations for how they would incorporate the many immunotherapy options into clinical pathways for patients with cutaneous melanoma. CONCLUSION: These clinical guidleines provide physicians and healthcare providers with consensus recommendations for managing melanoma patients electing treatment with tumor immunotherapy. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s40425-018-0362-6) contains supplementary material, which is available to authorized users.
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spelling pubmed-59775562018-06-06 An update on the Society for Immunotherapy of Cancer consensus statement on tumor immunotherapy for the treatment of cutaneous melanoma: version 2.0 Sullivan, Ryan J. Atkins, Michael B. Kirkwood, John M. Agarwala, Sanjiv S. Clark, Joseph I. Ernstoff, Marc S. Fecher, Leslie Gajewski, Thomas F. Gastman, Brian Lawson, David H. Lutzky, Jose McDermott, David F. Margolin, Kim A. Mehnert, Janice M. Pavlick, Anna C. Richards, Jon M. Rubin, Krista M. Sharfman, William Silverstein, Steven Slingluff, Craig L. Sondak, Vernon K. Tarhini, Ahmad A. Thompson, John A. Urba, Walter J. White, Richard L. Whitman, Eric D. Hodi, F. Stephen Kaufman, Howard L. J Immunother Cancer Position Article and Guidelines BACKGROUND: Cancer immunotherapy has been firmly established as a standard of care for patients with advanced and metastatic melanoma. Therapeutic outcomes in clinical trials have resulted in the approval of 11 new drugs and/or combination regimens for patients with melanoma. However, prospective data to support evidence-based clinical decisions with respect to the optimal schedule and sequencing of immunotherapy and targeted agents, how best to manage emerging toxicities and when to stop treatment are not yet available. METHODS: To address this knowledge gap, the Society for Immunotherapy of Cancer (SITC) Melanoma Task Force developed a process for consensus recommendations for physicians treating patients with melanoma integrating evidence-based data, where available, with best expert consensus opinion. The initial consensus statement was published in 2013, and version 2.0 of this report is an update based on a recent meeting of the Task Force and extensive subsequent discussions on new agents, contemporary peer-reviewed literature and emerging clinical data. The Academy of Medicine (formerly Institute of Medicine) clinical practice guidelines were used as a basis for consensus development with an updated literature search for important studies published between 1992 and 2017 and supplemented, as appropriate, by recommendations from Task Force participants. RESULTS: The Task Force considered patients with stage II-IV melanoma and here provide consensus recommendations for how they would incorporate the many immunotherapy options into clinical pathways for patients with cutaneous melanoma. CONCLUSION: These clinical guidleines provide physicians and healthcare providers with consensus recommendations for managing melanoma patients electing treatment with tumor immunotherapy. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s40425-018-0362-6) contains supplementary material, which is available to authorized users. BioMed Central 2018-05-30 /pmc/articles/PMC5977556/ /pubmed/29848375 http://dx.doi.org/10.1186/s40425-018-0362-6 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Position Article and Guidelines
Sullivan, Ryan J.
Atkins, Michael B.
Kirkwood, John M.
Agarwala, Sanjiv S.
Clark, Joseph I.
Ernstoff, Marc S.
Fecher, Leslie
Gajewski, Thomas F.
Gastman, Brian
Lawson, David H.
Lutzky, Jose
McDermott, David F.
Margolin, Kim A.
Mehnert, Janice M.
Pavlick, Anna C.
Richards, Jon M.
Rubin, Krista M.
Sharfman, William
Silverstein, Steven
Slingluff, Craig L.
Sondak, Vernon K.
Tarhini, Ahmad A.
Thompson, John A.
Urba, Walter J.
White, Richard L.
Whitman, Eric D.
Hodi, F. Stephen
Kaufman, Howard L.
An update on the Society for Immunotherapy of Cancer consensus statement on tumor immunotherapy for the treatment of cutaneous melanoma: version 2.0
title An update on the Society for Immunotherapy of Cancer consensus statement on tumor immunotherapy for the treatment of cutaneous melanoma: version 2.0
title_full An update on the Society for Immunotherapy of Cancer consensus statement on tumor immunotherapy for the treatment of cutaneous melanoma: version 2.0
title_fullStr An update on the Society for Immunotherapy of Cancer consensus statement on tumor immunotherapy for the treatment of cutaneous melanoma: version 2.0
title_full_unstemmed An update on the Society for Immunotherapy of Cancer consensus statement on tumor immunotherapy for the treatment of cutaneous melanoma: version 2.0
title_short An update on the Society for Immunotherapy of Cancer consensus statement on tumor immunotherapy for the treatment of cutaneous melanoma: version 2.0
title_sort update on the society for immunotherapy of cancer consensus statement on tumor immunotherapy for the treatment of cutaneous melanoma: version 2.0
topic Position Article and Guidelines
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977556/
https://www.ncbi.nlm.nih.gov/pubmed/29848375
http://dx.doi.org/10.1186/s40425-018-0362-6
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