Cargando…

Double conjugation strategy to incorporate lipid adjuvants into multiantigenic vaccines

Conjugation of multiple peptides by their N-termini is a promising technique to produce branched multiantigenic vaccines. We established a double conjugation strategy that combines a mercapto-acryloyl Michael addition and a copper-catalysed alkyne-azide 1,3-dipolar cycloaddition (CuAAC) reaction to...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hussein, Waleed M., Liu, Tzu-Yu, Maruthayanar, Pirashanthini, Mukaida, Saori, Moyle, Peter M., Wells, James W., Toth, Istvan, Skwarczynski, Mariusz
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2016
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977935/ https://www.ncbi.nlm.nih.gov/pubmed/29910921 http://dx.doi.org/10.1039/c5sc03859f

Ejemplares similares

Recent Advances in the Development of Peptide Vaccines and Their Delivery Systems against Group A Streptococcus
por: Azuar, Armira, et al.
Publicado: (2019)

Carbohydrate Immune Adjuvants in Subunit Vaccines
por: Bashiri, Sahra, et al.
Publicado: (2020)

Polyacrylate–Peptide Antigen Conjugate as a Single-Dose Oral Vaccine against Group A Streptococcus
por: Faruck, Mohammad Omer, et al.
Publicado: (2020)

Key Considerations for the Development of Safe and Effective SARS‐CoV‐2 Subunit Vaccine: A Peptide‐Based Vaccine Alternative
por: Shalash, Ahmed O., et al.
Publicado: (2021)

An Improved Tobacco Mosaic Virus (TMV)-Conjugated Multiantigen Subunit Vaccine Against Respiratory Tularemia
por: Mansour, Ahd A., et al.
Publicado: (2018)

Peptide Conjugation via CuAAC ‘Click’ Chemistry
por: Ahmad Fuaad, Abdullah A. H., et al.
Publicado: (2013)

Chemical Conjugation Strategies for the Development of Protein-Based Subunit Nanovaccines
por: Lu, Lantian, et al.
Publicado: (2021)

Peptide-Based Nanovaccines in the Treatment of Cervical Cancer: A Review of Recent Advances
por: Zhang, Jiahui, et al.
Publicado: (2022)

Peptide-based synthetic vaccines
por: Skwarczynski, Mariusz, et al.
Publicado: (2016)

Investigation of liposomal self-adjuvanting peptide epitopes derived from conserved blood-stage Plasmodium antigens
por: Islam, Md. Tanjir, et al.
Publicado: (2022)

Polyacrylate-GnRH Peptide Conjugate as an Oral Contraceptive Vaccine Candidate
por: Faruck, Mohammad O., et al.
Publicado: (2021)

Inulin: A New Adjuvant With Unknown Mode of Action
por: Skwarczynski, Mariusz
Publicado: (2016)

Editorial: Advances in Vaccine Delivery: Adjuvants, Carriers, Formulations, and Routes
por: Skwarczynski, Mariusz
Publicado: (2022)

A two-adjuvant multiantigen candidate vaccine induces superior protective immune responses against SARS-CoV-2 challenge
por: Jiang, Wenwen, et al.
Publicado: (2021)

The potential of developing a protective peptide‐based vaccines against SARS‐CoV‐2
por: Shalash, Ahmed O., et al.
Publicado: (2022)

Peptide-Based Vaccine against SARS-CoV-2: Peptide Antigen Discovery and Screening of Adjuvant Systems
por: Shalash, Ahmed O., et al.
Publicado: (2022)

Induction of high titred, non-neutralising antibodies by self-adjuvanting peptide epitopes derived from the respiratory syncytial virus fusion protein
por: Jaberolansar, Noushin, et al.
Publicado: (2017)

Liposomal Formulations of a Polyleucine–Antigen Conjugate as Therapeutic Vaccines against Cervical Cancer
por: Firdaus, Farrhana Z., et al.
Publicado: (2023)

Oral Peptide Vaccine against Hookworm Infection: Correlation of Antibody Titers with Protective Efficacy
por: Shalash, Ahmed O., et al.
Publicado: (2021)

The application of self-assembled nanostructures in peptide-based subunit vaccine development
por: Zhao, Guangzu, et al.
Publicado: (2017)

Poly(amino acids) as a potent self-adjuvanting delivery system for peptide-based nanovaccines
por: Skwarczynski, Mariusz, et al.
Publicado: (2020)

Advances in Infectious Disease Vaccine Adjuvants
por: Fan, Jingyi, et al.
Publicado: (2022)

Progress in the Development of Subunit Vaccines against Malaria
por: Skwarczynski, Mariusz, et al.
Publicado: (2020)

Cell-Penetrating Peptides-Based Liposomal Delivery System Enhanced Immunogenicity of Peptide-Based Vaccine against Group A Streptococcus
por: Yang, Jieru, et al.
Publicado: (2021)

Comparative Immune Phenotypic Analysis of Cutaneous Squamous Cell Carcinoma and Intraepidermal Carcinoma in Immune-Competent Individuals: Proportional Representation of CD8(+) T-Cells but Not FoxP3(+) Regulatory T-Cells Is Associated with Disease Stage
por: Freeman, Andrew, et al.
Publicado: (2014)

Anti-tumor activity of a T-helper 1 multiantigen vaccine in a murine model of prostate cancer
por: Cecil, Denise L., et al.
Publicado: (2022)

Development of Polyelectrolyte Complexes for the Delivery of Peptide-Based Subunit Vaccines against Group A Streptococcus
por: Zhao, Lili, et al.
Publicado: (2020)

Vaccination with Lipid Core Peptides Fails to Induce Epitope-Specific T Cell Responses but Confers Non-Specific Protective Immunity in a Malaria Model
por: Apte, Simon H., et al.
Publicado: (2012)

FtlA and FtlB Are Candidates for Inclusion in a Next-Generation Multiantigen Subunit Vaccine for Lyme Disease
por: Camire, Andrew C., et al.
Publicado: (2022)

Cell-Penetrating Peptides: Efficient Vectors for Vaccine Delivery
por: Yang, Jieru, et al.
Publicado: (2019)

Development and Evaluation of a Cryopreserved Whole-Parasite Vaccine in a Rodent Model of Blood-Stage Malaria
por: Stanisic, Danielle I., et al.
Publicado: (2021)

Fusion Expression and Immune Effect of PCV2 Cap Protein Tandem Multiantigen Epitopes with CD154/GM-CSF
por: Mao, Qian, et al.
Publicado: (2021)

Development of Multilayer Nanoparticles for the Delivery of Peptide-Based Subunit Vaccine against Group A Streptococcus
por: Kiong, Jolynn, et al.
Publicado: (2022)

Antimicrobial resistance and Neisseria gonorrhoeae multiantigen sequence typing (NG-MAST) genotypes in N. gonorrhoeae during 2012–2014 in Karachi, Pakistan
por: Jabeen, Kauser, et al.
Publicado: (2016)

Peptide-Based Subunit Vaccine against Hookworm Infection
por: Skwarczynski, Mariusz, et al.
Publicado: (2012)

Confinement of Triple-Enzyme-Involved Antioxidant Cascade in Two-Dimensional Nanostructure
por: Szerlauth, Adel, et al.
Publicado: (2023)

Synthetic multiantigen MVA vaccine COH04S1 protects against SARS-CoV-2 in Syrian hamsters and non-human primates
por: Chiuppesi, Flavia, et al.
Publicado: (2022)

Multiepitope Subunit Peptide-Based Nanovaccine against Porcine Circovirus Type 2 (PCV2) Elicited High Antibody Titers in Vaccinated Mice
por: Duong, Viet Tram, et al.
Publicado: (2023)

The Development of Surface-Modified Liposomes as an Intranasal Delivery System for Group A Streptococcus Vaccines
por: Yang, Jieru, et al.
Publicado: (2023)

Induction of Plasmodium-Specific Immune Responses Using Liposome-Based Vaccines
por: Ssemaganda, Aloysious, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_f7c1gdgkgl0f81diei0hs08kbn