Ancient Origin of the CARD–Coiled Coil/Bcl10/MALT1-Like Paracaspase Signaling Complex Indicates Unknown Critical Functions

The CARD–coiled coil (CC)/Bcl10/MALT1-like paracaspase (CBM) signaling complexes composed of a CARD–CC family member (CARD-9, -10, -11, or -14), Bcl10, and the type 1 paracaspase MALT1 (PCASP1) play a pivotal role in immunity, inflammation, and cancer. Targeting MALT1 proteolytic activity is of pote...

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Detalles Bibliográficos
Autores principales: Staal, Jens, Driege, Yasmine, Haegman, Mira, Borghi, Alice, Hulpiau, Paco, Lievens, Laurens, Gul, Ismail Sahin, Sundararaman, Srividhya, Gonçalves, Amanda, Dhondt, Ineke, Pinzón, Jorge H., Braeckman, Bart P., Technau, Ulrich, Saeys, Yvan, van Roy, Frans, Beyaert, Rudi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5978004/
https://www.ncbi.nlm.nih.gov/pubmed/29881386
http://dx.doi.org/10.3389/fimmu.2018.01136

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