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Nanoscale Topographical Characterization of Orbital Implant Materials
The search for an ideal orbital implant is still ongoing in the field of ocular biomaterials. Major limitations of currently-available porous implants include the high cost along with a non-negligible risk of exposure and postoperative infection due to conjunctival abrasion. In the effort to develop...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5978037/ https://www.ncbi.nlm.nih.gov/pubmed/29695125 http://dx.doi.org/10.3390/ma11050660 |
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author | Salerno, Marco Reverberi, Andrea Pietro Baino, Francesco |
author_facet | Salerno, Marco Reverberi, Andrea Pietro Baino, Francesco |
author_sort | Salerno, Marco |
collection | PubMed |
description | The search for an ideal orbital implant is still ongoing in the field of ocular biomaterials. Major limitations of currently-available porous implants include the high cost along with a non-negligible risk of exposure and postoperative infection due to conjunctival abrasion. In the effort to develop better alternatives to the existing devices, two types of new glass-ceramic porous implants were fabricated by sponge replication, which is a relatively inexpensive method. Then, they were characterized by direct three-dimensional (3D) contact probe mapping in real space by means of atomic force microscopy in order to assess their surface micro- and nano-features, which were quantitatively compared to those of the most commonly-used orbital implants. These silicate glass-ceramic materials exhibit a surface roughness in the range of a few hundred nanometers (S(q) within 500–700 nm) and topographical features comparable to those of clinically-used “gold-standard” alumina and polyethylene porous orbital implants. However, it was noted that both experimental and commercial non-porous implants were significantly smoother than all the porous ones. The results achieved in this work reveal that these porous glass-ceramic materials show promise for the intended application and encourage further investigation of their clinical suitability. |
format | Online Article Text |
id | pubmed-5978037 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-59780372018-05-31 Nanoscale Topographical Characterization of Orbital Implant Materials Salerno, Marco Reverberi, Andrea Pietro Baino, Francesco Materials (Basel) Article The search for an ideal orbital implant is still ongoing in the field of ocular biomaterials. Major limitations of currently-available porous implants include the high cost along with a non-negligible risk of exposure and postoperative infection due to conjunctival abrasion. In the effort to develop better alternatives to the existing devices, two types of new glass-ceramic porous implants were fabricated by sponge replication, which is a relatively inexpensive method. Then, they were characterized by direct three-dimensional (3D) contact probe mapping in real space by means of atomic force microscopy in order to assess their surface micro- and nano-features, which were quantitatively compared to those of the most commonly-used orbital implants. These silicate glass-ceramic materials exhibit a surface roughness in the range of a few hundred nanometers (S(q) within 500–700 nm) and topographical features comparable to those of clinically-used “gold-standard” alumina and polyethylene porous orbital implants. However, it was noted that both experimental and commercial non-porous implants were significantly smoother than all the porous ones. The results achieved in this work reveal that these porous glass-ceramic materials show promise for the intended application and encourage further investigation of their clinical suitability. MDPI 2018-04-24 /pmc/articles/PMC5978037/ /pubmed/29695125 http://dx.doi.org/10.3390/ma11050660 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Salerno, Marco Reverberi, Andrea Pietro Baino, Francesco Nanoscale Topographical Characterization of Orbital Implant Materials |
title | Nanoscale Topographical Characterization of Orbital Implant Materials |
title_full | Nanoscale Topographical Characterization of Orbital Implant Materials |
title_fullStr | Nanoscale Topographical Characterization of Orbital Implant Materials |
title_full_unstemmed | Nanoscale Topographical Characterization of Orbital Implant Materials |
title_short | Nanoscale Topographical Characterization of Orbital Implant Materials |
title_sort | nanoscale topographical characterization of orbital implant materials |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5978037/ https://www.ncbi.nlm.nih.gov/pubmed/29695125 http://dx.doi.org/10.3390/ma11050660 |
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