Cargando…

Nanoscale Topographical Characterization of Orbital Implant Materials

The search for an ideal orbital implant is still ongoing in the field of ocular biomaterials. Major limitations of currently-available porous implants include the high cost along with a non-negligible risk of exposure and postoperative infection due to conjunctival abrasion. In the effort to develop...

Descripción completa

Detalles Bibliográficos
Autores principales: Salerno, Marco, Reverberi, Andrea Pietro, Baino, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5978037/
https://www.ncbi.nlm.nih.gov/pubmed/29695125
http://dx.doi.org/10.3390/ma11050660
_version_ 1783327452567699456
author Salerno, Marco
Reverberi, Andrea Pietro
Baino, Francesco
author_facet Salerno, Marco
Reverberi, Andrea Pietro
Baino, Francesco
author_sort Salerno, Marco
collection PubMed
description The search for an ideal orbital implant is still ongoing in the field of ocular biomaterials. Major limitations of currently-available porous implants include the high cost along with a non-negligible risk of exposure and postoperative infection due to conjunctival abrasion. In the effort to develop better alternatives to the existing devices, two types of new glass-ceramic porous implants were fabricated by sponge replication, which is a relatively inexpensive method. Then, they were characterized by direct three-dimensional (3D) contact probe mapping in real space by means of atomic force microscopy in order to assess their surface micro- and nano-features, which were quantitatively compared to those of the most commonly-used orbital implants. These silicate glass-ceramic materials exhibit a surface roughness in the range of a few hundred nanometers (S(q) within 500–700 nm) and topographical features comparable to those of clinically-used “gold-standard” alumina and polyethylene porous orbital implants. However, it was noted that both experimental and commercial non-porous implants were significantly smoother than all the porous ones. The results achieved in this work reveal that these porous glass-ceramic materials show promise for the intended application and encourage further investigation of their clinical suitability.
format Online
Article
Text
id pubmed-5978037
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-59780372018-05-31 Nanoscale Topographical Characterization of Orbital Implant Materials Salerno, Marco Reverberi, Andrea Pietro Baino, Francesco Materials (Basel) Article The search for an ideal orbital implant is still ongoing in the field of ocular biomaterials. Major limitations of currently-available porous implants include the high cost along with a non-negligible risk of exposure and postoperative infection due to conjunctival abrasion. In the effort to develop better alternatives to the existing devices, two types of new glass-ceramic porous implants were fabricated by sponge replication, which is a relatively inexpensive method. Then, they were characterized by direct three-dimensional (3D) contact probe mapping in real space by means of atomic force microscopy in order to assess their surface micro- and nano-features, which were quantitatively compared to those of the most commonly-used orbital implants. These silicate glass-ceramic materials exhibit a surface roughness in the range of a few hundred nanometers (S(q) within 500–700 nm) and topographical features comparable to those of clinically-used “gold-standard” alumina and polyethylene porous orbital implants. However, it was noted that both experimental and commercial non-porous implants were significantly smoother than all the porous ones. The results achieved in this work reveal that these porous glass-ceramic materials show promise for the intended application and encourage further investigation of their clinical suitability. MDPI 2018-04-24 /pmc/articles/PMC5978037/ /pubmed/29695125 http://dx.doi.org/10.3390/ma11050660 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Salerno, Marco
Reverberi, Andrea Pietro
Baino, Francesco
Nanoscale Topographical Characterization of Orbital Implant Materials
title Nanoscale Topographical Characterization of Orbital Implant Materials
title_full Nanoscale Topographical Characterization of Orbital Implant Materials
title_fullStr Nanoscale Topographical Characterization of Orbital Implant Materials
title_full_unstemmed Nanoscale Topographical Characterization of Orbital Implant Materials
title_short Nanoscale Topographical Characterization of Orbital Implant Materials
title_sort nanoscale topographical characterization of orbital implant materials
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5978037/
https://www.ncbi.nlm.nih.gov/pubmed/29695125
http://dx.doi.org/10.3390/ma11050660
work_keys_str_mv AT salernomarco nanoscaletopographicalcharacterizationoforbitalimplantmaterials
AT reverberiandreapietro nanoscaletopographicalcharacterizationoforbitalimplantmaterials
AT bainofrancesco nanoscaletopographicalcharacterizationoforbitalimplantmaterials