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The Multifaceted Uses and Therapeutic Advantages of Nanoparticles for Atherosclerosis Research

Nanoparticles are uniquely suited for the study and development of potential therapies against atherosclerosis by virtue of their size, fine-tunable properties, and ability to incorporate therapies and/or imaging modalities. Furthermore, nanoparticles can be specifically targeted to the atherosclero...

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Autores principales: DiStasio, Nicholas, Lehoux, Stephanie, Khademhosseini, Ali, Tabrizian, Maryam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5978131/
https://www.ncbi.nlm.nih.gov/pubmed/29738480
http://dx.doi.org/10.3390/ma11050754
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author DiStasio, Nicholas
Lehoux, Stephanie
Khademhosseini, Ali
Tabrizian, Maryam
author_facet DiStasio, Nicholas
Lehoux, Stephanie
Khademhosseini, Ali
Tabrizian, Maryam
author_sort DiStasio, Nicholas
collection PubMed
description Nanoparticles are uniquely suited for the study and development of potential therapies against atherosclerosis by virtue of their size, fine-tunable properties, and ability to incorporate therapies and/or imaging modalities. Furthermore, nanoparticles can be specifically targeted to the atherosclerotic plaque, evading off-target effects and/or associated cytotoxicity. There has been a wealth of knowledge available concerning the use of nanotechnologies in cardiovascular disease and atherosclerosis, in particular in animal models, but with a major focus on imaging agents. In fact, roughly 60% of articles from an initial search for this review included examples of imaging applications of nanoparticles. Thus, this review focuses on experimental therapy interventions applied to and observed in animal models. Particular emphasis is placed on how nanoparticle materials and properties allow researchers to learn a great deal about atherosclerosis. The objective of this review was to provide an update for nanoparticle use in imaging and drug delivery studies and to illustrate how nanoparticles can be used for sensing and modelling, for studying fundamental biological mechanisms, and for the delivery of biotherapeutics such as proteins, peptides, nucleic acids, and even cells all with the goal of attenuating atherosclerosis. Furthermore, the various atherosclerosis processes targeted mainly for imaging studies have been summarized in the hopes of inspiring new and exciting targeted therapeutic and/or imaging strategies.
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spelling pubmed-59781312018-05-31 The Multifaceted Uses and Therapeutic Advantages of Nanoparticles for Atherosclerosis Research DiStasio, Nicholas Lehoux, Stephanie Khademhosseini, Ali Tabrizian, Maryam Materials (Basel) Review Nanoparticles are uniquely suited for the study and development of potential therapies against atherosclerosis by virtue of their size, fine-tunable properties, and ability to incorporate therapies and/or imaging modalities. Furthermore, nanoparticles can be specifically targeted to the atherosclerotic plaque, evading off-target effects and/or associated cytotoxicity. There has been a wealth of knowledge available concerning the use of nanotechnologies in cardiovascular disease and atherosclerosis, in particular in animal models, but with a major focus on imaging agents. In fact, roughly 60% of articles from an initial search for this review included examples of imaging applications of nanoparticles. Thus, this review focuses on experimental therapy interventions applied to and observed in animal models. Particular emphasis is placed on how nanoparticle materials and properties allow researchers to learn a great deal about atherosclerosis. The objective of this review was to provide an update for nanoparticle use in imaging and drug delivery studies and to illustrate how nanoparticles can be used for sensing and modelling, for studying fundamental biological mechanisms, and for the delivery of biotherapeutics such as proteins, peptides, nucleic acids, and even cells all with the goal of attenuating atherosclerosis. Furthermore, the various atherosclerosis processes targeted mainly for imaging studies have been summarized in the hopes of inspiring new and exciting targeted therapeutic and/or imaging strategies. MDPI 2018-05-08 /pmc/articles/PMC5978131/ /pubmed/29738480 http://dx.doi.org/10.3390/ma11050754 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
DiStasio, Nicholas
Lehoux, Stephanie
Khademhosseini, Ali
Tabrizian, Maryam
The Multifaceted Uses and Therapeutic Advantages of Nanoparticles for Atherosclerosis Research
title The Multifaceted Uses and Therapeutic Advantages of Nanoparticles for Atherosclerosis Research
title_full The Multifaceted Uses and Therapeutic Advantages of Nanoparticles for Atherosclerosis Research
title_fullStr The Multifaceted Uses and Therapeutic Advantages of Nanoparticles for Atherosclerosis Research
title_full_unstemmed The Multifaceted Uses and Therapeutic Advantages of Nanoparticles for Atherosclerosis Research
title_short The Multifaceted Uses and Therapeutic Advantages of Nanoparticles for Atherosclerosis Research
title_sort multifaceted uses and therapeutic advantages of nanoparticles for atherosclerosis research
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5978131/
https://www.ncbi.nlm.nih.gov/pubmed/29738480
http://dx.doi.org/10.3390/ma11050754
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