Neurofibromin level directs RAS pathway signaling and mediates sensitivity to targeted agents in malignant peripheral nerve sheath tumors

Malignant peripheral nerve sheath tumor (MPNST) is a type of soft-tissue sarcoma strongly associated with dysfunction in neurofibromin; an inhibitor of the RAS pathway. We performed high-throughput screening of an array of FDA approved and promising agents in clinical development both alone and in c...

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Detalles Bibliográficos
Autores principales: Kahen, Elliot John, Brohl, Andrew, Yu, Diana, Welch, Darcy, Cubitt, Christopher L., Lee, Jae K., Chen, Yunyun, Yoder, Sean J., Teer, Jamie K., Zhang, Yonghong O., Wallace, Margaret R., Reed, Damon R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5978249/
https://www.ncbi.nlm.nih.gov/pubmed/29854299
http://dx.doi.org/10.18632/oncotarget.25181

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