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Inhibiting Janus Kinase 1 and BCL-2 to treat T cell acute lymphoblastic leukemia with IL7-Rα mutations

Acute lymphoblastic leukemia (ALL) is the most common cancer in children. Current chemotherapy is quite toxic in growing children and more directed therapeutics are being sought. The IL-7R pathway is a major driver of ALL and here we evaluate two drugs directed to that pathway using a model of T cel...

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Detalles Bibliográficos
Autores principales:	Senkevitch, Emilee, Li, Wenqing, Hixon, Julie A., Andrews, Caroline, Cramer, Sarah D., Pauly, Gary T., Back, Timothy, Czarra, Kelli, Durum, Scott K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5978251/ https://www.ncbi.nlm.nih.gov/pubmed/29854301 http://dx.doi.org/10.18632/oncotarget.25194

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