Cargando…

Simultaneous identification of clinically relevant single nucleotide variants, copy number alterations and gene fusions in solid tumors by targeted next-generation sequencing

In this study, we have set-up a routine pipeline to evaluate the clinical application of Oncomine™ Focus Assay, a panel that allows the simultaneous detection of single nucleotide hotspot mutations in 35 genes, copy number alterations (CNAs) in 19 genes and gene fusions involving 23 genes in cancer...

Descripción completa

Detalles Bibliográficos
Autores principales:	Oliveira, Duarte Mendes, Mirante, Teresa, Mignogna, Chiara, Scrima, Marianna, Migliozzi, Simona, Rocco, Gaetano, Franco, Renato, Corcione, Francesco, Viglietto, Giuseppe, Malanga, Donatella, Rizzuto, Antonia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5978263/ https://www.ncbi.nlm.nih.gov/pubmed/29854313 http://dx.doi.org/10.18632/oncotarget.25229

Ejemplares similares

Identification of copy number alterations in colon cancer from analysis of amplicon-based next generation sequencing data
por: Oliveira, Duarte Mendes, et al.
Publicado: (2018)

Identification of different mutational profiles in cancers arising in specific colon segments by next generation sequencing
por: Oliveira, Duarte Mendes, et al.
Publicado: (2018)

Next-generation sequencing analysis of receptor-type tyrosine kinase genes in surgically resected colon cancer: identification of gain-of-function mutations in the RET proto-oncogene
por: Mendes Oliveira, Duarte, et al.
Publicado: (2018)

Correction to: Next-generation sequencing analysis of receptor-type tyrosine kinase genes in surgically resected colon cancer: identification of gain-of-function mutations in the RET proto-oncogene
por: Oliveira, Duarte Mendes, et al.
Publicado: (2018)

Aberrant Signaling through the HER2-ERK1/2 Pathway is Predictive of Reduced Disease-Free and Overall Survival in Early Stage Non-Small Cell Lung Cancer (NSCLC) Patients
por: Scrima, Marianna, et al.
Publicado: (2017)

AKT1(E17K) Is Oncogenic in Mouse Lung and Cooperates with Chemical Carcinogens in Inducing Lung Cancer
por: Malanga, Donatella, et al.
Publicado: (2016)

The Akt1/IL-6/STAT3 pathway regulates growth of lung tumor initiating cells
por: Malanga, Donatella, et al.
Publicado: (2015)

Mutant AKT1-E17K is oncogenic in lung epithelial cells
por: De Marco, Carmela, et al.
Publicado: (2015)

Signaling Networks Associated with AKT Activation in Non-Small Cell Lung Cancer (NSCLC): New Insights on the Role of Phosphatydil-Inositol-3 kinase
por: Scrima, Marianna, et al.
Publicado: (2012)

The AKT1E17K Allele Promotes Breast Cancer in Mice
por: Malanga, Donatella, et al.
Publicado: (2022)

Analysis of miRNA profiles identified miR-196a as a crucial mediator of aberrant PI3K/AKT signaling in lung cancer cells
por: Guerriero, Ilaria, et al.
Publicado: (2016)

Correction: Analysis of miRNA profiles identified miR-196a as a crucial mediator of aberrant PI3K/AKT signaling in lung cancer cells
por: Guerriero, Ilaria, et al.
Publicado: (2022)

Specific gene expression signatures induced by the multiple oncogenic alterations that occur within the PTEN/PI3K/AKT pathway in lung cancer
por: De Marco, Carmela, et al.
Publicado: (2017)

Genome-wide analysis of copy number alterations led to the characterisation of PDCD10 as oncogene in ovarian cancer
por: De Marco, Carmela, et al.
Publicado: (2021)

Simultaneous Detection of Both Single Nucleotide Variations and Copy Number Alterations by Next-Generation Sequencing in Gorlin Syndrome
por: Morita, Kei-ichi, et al.
Publicado: (2015)

Detection of Single-Nucleotide and Copy Number Defects Underlying Hyperphenylalaninemia by Next-Generation Sequencing
por: Tendi, Elisabetta Anna, et al.
Publicado: (2023)

Detection of Natural Resistance-Associated Substitutions by Ion Semiconductor Technology in HCV1b Positive, Direct-Acting Antiviral Agents-Naïve Patients
por: Marascio, Nadia, et al.
Publicado: (2016)

Harnessing the value of TCTP in breast cancer treatment resistance: an opportunity for personalized therapy
por: Santamaria, Gianluca, et al.
Publicado: (2023)

Simultaneous Copy Number Alteration and Single-Nucleotide Variation Analysis in Matched Aqueous Humor and Tumor Samples in Children with Retinoblastoma
por: Schmidt, Michael J., et al.
Publicado: (2023)

Laparoscopic splenectomy for a simultaneous wandering spleen along with an ectopic accessory spleen. Case report and review of the literature
por: Rizzuto, Antonia, et al.
Publicado: (2018)

Nucleotide polymorphism and copy number variant detection using exome capture and next-generation sequencing in the polyploid grass Panicum virgatum
por: Evans, Joseph, et al.
Publicado: (2014)

Ferritin heavy subunit enhances apoptosis of non-small cell lung cancer cells through modulation of miR-125b/p53 axis
por: Biamonte, Flavia, et al.
Publicado: (2018)

Multiple Genetic Alterations within the PI3K Pathway Are Responsible for AKT Activation in Patients with Ovarian Carcinoma
por: De Marco, Carmela, et al.
Publicado: (2013)

Next generation long baseline experiments on the path to leptonic CP violation
por: Migliozzi, P, et al.
Publicado: (2003)

Unproductive Effects of ALK Gene Amplification and Copy Number Gain in Non-Small-Cell Lung Cancer. ALK Gene Amplification and Copy Gain in NSCLC
por: Zito Marino, Federica, et al.
Publicado: (2020)

Enhanced Nonenzymatic RNA Copying with 2-Aminoimidazole Activated Nucleotides
por: Li, Li, et al.
Publicado: (2017)

Postoperative Morbidity Following Loop Ileostomy Reversal after Primary Elective or Urgent Surgery: A Retrospective Study with 145 Patients
por: Peltrini, Roberto, et al.
Publicado: (2023)

Quantitative Analysis of Single Nucleotide Polymorphisms within Copy Number Variation
por: Lee, Soohyun, et al.
Publicado: (2008)

VCS: Tool for Visualizing Copy Number Variation and Single Nucleotide Polymorphism
por: Kim, HyoYoung, et al.
Publicado: (2014)

Small-Molecule Organocatalysis Facilitates In Situ Nucleotide Activation and RNA Copying
por: Aitken, Harry R. M., et al.
Publicado: (2023)

Virtual Terminator nucleotides for next generation DNA sequencing
por: Bowers, Jayson, et al.
Publicado: (2009)

Bayesian estimation of genomic copy number with single nucleotide polymorphism genotyping arrays
por: Guo, Beibei, et al.
Publicado: (2010)

Allele-specific copy number profiling by next-generation DNA sequencing
por: Chen, Hao, et al.
Publicado: (2015)

Irreversible electroporation for locally advanced pancreatic cancer through a minimally invasive surgery supported by laparoscopic ultrasound
por: Tartaglia, Ernesto, et al.
Publicado: (2017)

Targeted analysis of nucleotide and copy number variation by exon capture in allotetraploid wheat genome
por: Saintenac, Cyrille, et al.
Publicado: (2011)

Copy number and nucleotide variation of the LILR family of myelomonocytic cell activating and inhibitory receptors
por: López-Álvarez, María R., et al.
Publicado: (2013)

Next-generation sequencing technologies for detection of modified nucleotides in RNAs
por: Schwartz, Schraga, et al.
Publicado: (2016)

Prognostic relevance of mutations and copy number alterations assessed with targeted next generation sequencing in IDH mutant grade II glioma
por: Wijnenga, Maarten M. J., et al.
Publicado: (2018)

Simultaneous detection of genetic and copy number alterations in BRCA1/2 genes
por: Hirotsu, Yosuke, et al.
Publicado: (2017)

Precise and simultaneous quantification of mitochondrial DNA heteroplasmy and copy number by digital PCR
por: Shoop, Wendy K., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_258hq0i0klj8d1mn3a0336dppk