5-Hydroxymethylcytosine preferentially targets genes upregulated in isocitrate dehydrogenase 1 mutant high-grade glioma

Gliomas demonstrate epigenetic dysregulation exemplified by the Glioma CpG Island Methylator Phenotype (G-CIMP) seen in IDH1 mutant tumors. 5-Hydroxymethylcytosine (5hmC) is implicated in glioma pathogenesis; however, its role in IDH1 mutant gliomas is incompletely understood. To characterize 5hmC i...

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Detalles Bibliográficos
Autores principales: Glowacka, Wioletta K., Jain, Harshika, Okura, Makiko, Maimaitiming, Abulizi, Mamatjan, Yasin, Nejad, Romina, Farooq, Hamza, Taylor, Michael D., Aldape, Kenneth, Kongkham, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5978937/
https://www.ncbi.nlm.nih.gov/pubmed/29428975
http://dx.doi.org/10.1007/s00401-018-1821-3

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