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PARP1 depletion improves mitochondrial and heart function in Chagas disease: Effects on POLG dependent mtDNA maintenance

Chagasic cardiomyopathy is caused by Trypanosoma cruzi infection. Poly(ADP-ribose) polymerase 1 (PARP1) is known for its function in nuclear DNA repair. In this study, we have employed genetic deletion and chemical inhibition approaches to determine the role of PARP1 in maintaining mtDNA dependent m...

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Detalles Bibliográficos
Autores principales:	Wen, Jake Jianjun, Yin, Yuhui Whitney, Garg, Nisha Jain
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5979003/ https://www.ncbi.nlm.nih.gov/pubmed/29851986 http://dx.doi.org/10.1371/journal.ppat.1007065

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