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Reduced ITPase activity and favorable IL28B genetic variant protect against ribavirin-induced anemia in interferon-free regimens

BACKGROUND: Genetic variants of inosine triphosphatase (ITPA) that confer reduced ITPase activity are associated with protection against ribavirin(RBV)-induced hemolytic anemia in peginterferon(IFN)/RBV-based treatment of hepatitis C virus (HCV). Patients with reduced ITPase activity showed improved...

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Detalles Bibliográficos
Autores principales:	Vasanthakumar, Aparna, Davis, Justin W., Abunimeh, Manal, Söderholm, Jonas, Zha, Jiuhong, Dumas, Emily O., Cohen, Daniel E., Waring, Jeffrey F., Lagging, Martin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5979032/ https://www.ncbi.nlm.nih.gov/pubmed/29851985 http://dx.doi.org/10.1371/journal.pone.0198296

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