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Mechanisms of ATP Release by Inflammatory Cells
Extracellular nucleotides (e.g., ATP, ADP, UTP, UDP) released by inflammatory cells interact with specific purinergic P2 type receptors to modulate their recruitment and activation. The focus of this review is on stimuli and mechanisms of extracellular nucleotide release and its consequences during...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5979498/ https://www.ncbi.nlm.nih.gov/pubmed/29669994 http://dx.doi.org/10.3390/ijms19041222 |
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author | Dosch, Michel Gerber, Joël Jebbawi, Fadi Beldi, Guido |
author_facet | Dosch, Michel Gerber, Joël Jebbawi, Fadi Beldi, Guido |
author_sort | Dosch, Michel |
collection | PubMed |
description | Extracellular nucleotides (e.g., ATP, ADP, UTP, UDP) released by inflammatory cells interact with specific purinergic P2 type receptors to modulate their recruitment and activation. The focus of this review is on stimuli and mechanisms of extracellular nucleotide release and its consequences during inflammation. Necrosis leads to non-specific release of nucleotides, whereas specific release mechanisms include vesicular exocytosis and channel-mediated release via connexin or pannexin hemichannels. These release mechanisms allow stimulated inflammatory cells such as macrophages, neutrophils, and endothelial cells to fine-tune autocrine/paracrine responses during acute and chronic inflammation. Key effector functions of inflammatory cells are therefore regulated by purinergic signaling in acute and chronic diseases, making extracellular nucleotide release a promising target for the development of new therapies. |
format | Online Article Text |
id | pubmed-5979498 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-59794982018-06-10 Mechanisms of ATP Release by Inflammatory Cells Dosch, Michel Gerber, Joël Jebbawi, Fadi Beldi, Guido Int J Mol Sci Review Extracellular nucleotides (e.g., ATP, ADP, UTP, UDP) released by inflammatory cells interact with specific purinergic P2 type receptors to modulate their recruitment and activation. The focus of this review is on stimuli and mechanisms of extracellular nucleotide release and its consequences during inflammation. Necrosis leads to non-specific release of nucleotides, whereas specific release mechanisms include vesicular exocytosis and channel-mediated release via connexin or pannexin hemichannels. These release mechanisms allow stimulated inflammatory cells such as macrophages, neutrophils, and endothelial cells to fine-tune autocrine/paracrine responses during acute and chronic inflammation. Key effector functions of inflammatory cells are therefore regulated by purinergic signaling in acute and chronic diseases, making extracellular nucleotide release a promising target for the development of new therapies. MDPI 2018-04-18 /pmc/articles/PMC5979498/ /pubmed/29669994 http://dx.doi.org/10.3390/ijms19041222 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Dosch, Michel Gerber, Joël Jebbawi, Fadi Beldi, Guido Mechanisms of ATP Release by Inflammatory Cells |
title | Mechanisms of ATP Release by Inflammatory Cells |
title_full | Mechanisms of ATP Release by Inflammatory Cells |
title_fullStr | Mechanisms of ATP Release by Inflammatory Cells |
title_full_unstemmed | Mechanisms of ATP Release by Inflammatory Cells |
title_short | Mechanisms of ATP Release by Inflammatory Cells |
title_sort | mechanisms of atp release by inflammatory cells |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5979498/ https://www.ncbi.nlm.nih.gov/pubmed/29669994 http://dx.doi.org/10.3390/ijms19041222 |
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