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Gut Microbiota and Type 1 Diabetes
Recently, the onset of type 1 diabetes (T1D) has increased rapidly and became a major public health concern worldwide. Various factors are associated with the development of T1D, such as diet, genome, and intestinal microbiota. The gastrointestinal (GI) tract harbors a complex and dynamic population...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5979537/ https://www.ncbi.nlm.nih.gov/pubmed/29584630 http://dx.doi.org/10.3390/ijms19040995 |
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author | Han, Hui Li, Yuying Fang, Jun Liu, Gang Yin, Jie Li, Tiejun Yin, Yulong |
author_facet | Han, Hui Li, Yuying Fang, Jun Liu, Gang Yin, Jie Li, Tiejun Yin, Yulong |
author_sort | Han, Hui |
collection | PubMed |
description | Recently, the onset of type 1 diabetes (T1D) has increased rapidly and became a major public health concern worldwide. Various factors are associated with the development of T1D, such as diet, genome, and intestinal microbiota. The gastrointestinal (GI) tract harbors a complex and dynamic population of microorganisms, the gut microbiota, which exert a marked influence on the host homeostasis and metabolic diseases. Recent evidence shows that altered gut bacterial composition (dysbiosis) is highly associated with the pathogenesis of insulin dysfunction and T1D and, thus, targeting gut microbiota may serve as a therapeutic potential for T1D patients. In this study, we updated the effect of gut microbiota on T1D and potential mechanisms were discussed. |
format | Online Article Text |
id | pubmed-5979537 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-59795372018-06-10 Gut Microbiota and Type 1 Diabetes Han, Hui Li, Yuying Fang, Jun Liu, Gang Yin, Jie Li, Tiejun Yin, Yulong Int J Mol Sci Review Recently, the onset of type 1 diabetes (T1D) has increased rapidly and became a major public health concern worldwide. Various factors are associated with the development of T1D, such as diet, genome, and intestinal microbiota. The gastrointestinal (GI) tract harbors a complex and dynamic population of microorganisms, the gut microbiota, which exert a marked influence on the host homeostasis and metabolic diseases. Recent evidence shows that altered gut bacterial composition (dysbiosis) is highly associated with the pathogenesis of insulin dysfunction and T1D and, thus, targeting gut microbiota may serve as a therapeutic potential for T1D patients. In this study, we updated the effect of gut microbiota on T1D and potential mechanisms were discussed. MDPI 2018-03-27 /pmc/articles/PMC5979537/ /pubmed/29584630 http://dx.doi.org/10.3390/ijms19040995 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Han, Hui Li, Yuying Fang, Jun Liu, Gang Yin, Jie Li, Tiejun Yin, Yulong Gut Microbiota and Type 1 Diabetes |
title | Gut Microbiota and Type 1 Diabetes |
title_full | Gut Microbiota and Type 1 Diabetes |
title_fullStr | Gut Microbiota and Type 1 Diabetes |
title_full_unstemmed | Gut Microbiota and Type 1 Diabetes |
title_short | Gut Microbiota and Type 1 Diabetes |
title_sort | gut microbiota and type 1 diabetes |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5979537/ https://www.ncbi.nlm.nih.gov/pubmed/29584630 http://dx.doi.org/10.3390/ijms19040995 |
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