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Gut Microbiota and Type 1 Diabetes

Recently, the onset of type 1 diabetes (T1D) has increased rapidly and became a major public health concern worldwide. Various factors are associated with the development of T1D, such as diet, genome, and intestinal microbiota. The gastrointestinal (GI) tract harbors a complex and dynamic population...

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Autores principales: Han, Hui, Li, Yuying, Fang, Jun, Liu, Gang, Yin, Jie, Li, Tiejun, Yin, Yulong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5979537/
https://www.ncbi.nlm.nih.gov/pubmed/29584630
http://dx.doi.org/10.3390/ijms19040995
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author Han, Hui
Li, Yuying
Fang, Jun
Liu, Gang
Yin, Jie
Li, Tiejun
Yin, Yulong
author_facet Han, Hui
Li, Yuying
Fang, Jun
Liu, Gang
Yin, Jie
Li, Tiejun
Yin, Yulong
author_sort Han, Hui
collection PubMed
description Recently, the onset of type 1 diabetes (T1D) has increased rapidly and became a major public health concern worldwide. Various factors are associated with the development of T1D, such as diet, genome, and intestinal microbiota. The gastrointestinal (GI) tract harbors a complex and dynamic population of microorganisms, the gut microbiota, which exert a marked influence on the host homeostasis and metabolic diseases. Recent evidence shows that altered gut bacterial composition (dysbiosis) is highly associated with the pathogenesis of insulin dysfunction and T1D and, thus, targeting gut microbiota may serve as a therapeutic potential for T1D patients. In this study, we updated the effect of gut microbiota on T1D and potential mechanisms were discussed.
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spelling pubmed-59795372018-06-10 Gut Microbiota and Type 1 Diabetes Han, Hui Li, Yuying Fang, Jun Liu, Gang Yin, Jie Li, Tiejun Yin, Yulong Int J Mol Sci Review Recently, the onset of type 1 diabetes (T1D) has increased rapidly and became a major public health concern worldwide. Various factors are associated with the development of T1D, such as diet, genome, and intestinal microbiota. The gastrointestinal (GI) tract harbors a complex and dynamic population of microorganisms, the gut microbiota, which exert a marked influence on the host homeostasis and metabolic diseases. Recent evidence shows that altered gut bacterial composition (dysbiosis) is highly associated with the pathogenesis of insulin dysfunction and T1D and, thus, targeting gut microbiota may serve as a therapeutic potential for T1D patients. In this study, we updated the effect of gut microbiota on T1D and potential mechanisms were discussed. MDPI 2018-03-27 /pmc/articles/PMC5979537/ /pubmed/29584630 http://dx.doi.org/10.3390/ijms19040995 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Han, Hui
Li, Yuying
Fang, Jun
Liu, Gang
Yin, Jie
Li, Tiejun
Yin, Yulong
Gut Microbiota and Type 1 Diabetes
title Gut Microbiota and Type 1 Diabetes
title_full Gut Microbiota and Type 1 Diabetes
title_fullStr Gut Microbiota and Type 1 Diabetes
title_full_unstemmed Gut Microbiota and Type 1 Diabetes
title_short Gut Microbiota and Type 1 Diabetes
title_sort gut microbiota and type 1 diabetes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5979537/
https://www.ncbi.nlm.nih.gov/pubmed/29584630
http://dx.doi.org/10.3390/ijms19040995
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