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Ursodeoxycholate Restores Biliary Excretion of Methotrexate in Rats with Ethinyl Estradiol Induced-Cholestasis by Restoring Canalicular Mrp2 Expression

The in vivo relevance of ursodeoxycholate (UDCA) treatment (100 mg/kg/day, per oral tid for 5 days before cholestasis induction followed by the same dosing for 5 days) on hepatic function was investigated in rats with 17α-ethinylestradiol (EE, 10 mg/kg, subcutaneous for 5 days)-induced experimental...

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Detalles Bibliográficos
Autores principales:	Kim, Min Ju, Kang, Yun Ju, Kwon, Mihwa, Choi, Young A., Choi, Min-Koo, Chi, Hye-Young, Yoo, Hye Hyun, Shim, Chang-Koo, Song, Im-Sook
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5979538/ https://www.ncbi.nlm.nih.gov/pubmed/29642532 http://dx.doi.org/10.3390/ijms19041120

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