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The Crystal Structure of the R280K Mutant of Human p53 Explains the Loss of DNA Binding

The p53 tumor suppressor is widely found to be mutated in human cancer. This protein is regarded as a molecular hub regulating different cell responses, namely cell death. Compelling data have demonstrated that the impairment of p53 activity correlates with tumor development and maintenance. For the...

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Detalles Bibliográficos
Autores principales:	Gomes, Ana Sara, Trovão, Filipa, Andrade Pinheiro, Benedita, Freire, Filipe, Gomes, Sara, Oliveira, Carla, Domingues, Lucília, Romão, Maria João, Saraiva, Lucília, Carvalho, Ana Luísa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5979565/ https://www.ncbi.nlm.nih.gov/pubmed/29652801 http://dx.doi.org/10.3390/ijms19041184

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