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Migration/Invasion of Malignant Gliomas and Implications for Therapeutic Treatment
Malignant tumors of the central nervous system (CNS) are among cancers with the poorest prognosis, indicated by their association with tumors of high-level morbidity and mortality. Gliomas, the most common primary CNS tumors that arise from neuroglial stem or progenitor cells, have estimated annual...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5979613/ https://www.ncbi.nlm.nih.gov/pubmed/29642503 http://dx.doi.org/10.3390/ijms19041115 |
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author | Liu, Ching-Ann Chang, Chia-Yu Hsueh, Kuo-Wei Su, Hong-Lin Chiou, Tzyy-Wen Lin, Shinn-Zong Harn, Horng-Jyh |
author_facet | Liu, Ching-Ann Chang, Chia-Yu Hsueh, Kuo-Wei Su, Hong-Lin Chiou, Tzyy-Wen Lin, Shinn-Zong Harn, Horng-Jyh |
author_sort | Liu, Ching-Ann |
collection | PubMed |
description | Malignant tumors of the central nervous system (CNS) are among cancers with the poorest prognosis, indicated by their association with tumors of high-level morbidity and mortality. Gliomas, the most common primary CNS tumors that arise from neuroglial stem or progenitor cells, have estimated annual incidence of 6.6 per 100,000 individuals in the USA, and 3.5 per 100,000 individuals in Taiwan. Tumor invasion and metastasis are the major contributors to the deaths in cancer patients. Therapeutic goals including cancer stem cells (CSC), phenotypic shifts, EZH2/AXL/TGF-β axis activation, miRNAs and exosomes are relevant to GBM metastasis to develop novel targeted therapeutics for GBM and other brain cancers. Herein, we highlight tumor metastasis in our understanding of gliomas, and illustrate novel exosome therapeutic approaches in glioma, thereby paving the way towards innovative therapies in neuro-oncology. |
format | Online Article Text |
id | pubmed-5979613 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-59796132018-06-10 Migration/Invasion of Malignant Gliomas and Implications for Therapeutic Treatment Liu, Ching-Ann Chang, Chia-Yu Hsueh, Kuo-Wei Su, Hong-Lin Chiou, Tzyy-Wen Lin, Shinn-Zong Harn, Horng-Jyh Int J Mol Sci Review Malignant tumors of the central nervous system (CNS) are among cancers with the poorest prognosis, indicated by their association with tumors of high-level morbidity and mortality. Gliomas, the most common primary CNS tumors that arise from neuroglial stem or progenitor cells, have estimated annual incidence of 6.6 per 100,000 individuals in the USA, and 3.5 per 100,000 individuals in Taiwan. Tumor invasion and metastasis are the major contributors to the deaths in cancer patients. Therapeutic goals including cancer stem cells (CSC), phenotypic shifts, EZH2/AXL/TGF-β axis activation, miRNAs and exosomes are relevant to GBM metastasis to develop novel targeted therapeutics for GBM and other brain cancers. Herein, we highlight tumor metastasis in our understanding of gliomas, and illustrate novel exosome therapeutic approaches in glioma, thereby paving the way towards innovative therapies in neuro-oncology. MDPI 2018-04-08 /pmc/articles/PMC5979613/ /pubmed/29642503 http://dx.doi.org/10.3390/ijms19041115 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Liu, Ching-Ann Chang, Chia-Yu Hsueh, Kuo-Wei Su, Hong-Lin Chiou, Tzyy-Wen Lin, Shinn-Zong Harn, Horng-Jyh Migration/Invasion of Malignant Gliomas and Implications for Therapeutic Treatment |
title | Migration/Invasion of Malignant Gliomas and Implications for Therapeutic Treatment |
title_full | Migration/Invasion of Malignant Gliomas and Implications for Therapeutic Treatment |
title_fullStr | Migration/Invasion of Malignant Gliomas and Implications for Therapeutic Treatment |
title_full_unstemmed | Migration/Invasion of Malignant Gliomas and Implications for Therapeutic Treatment |
title_short | Migration/Invasion of Malignant Gliomas and Implications for Therapeutic Treatment |
title_sort | migration/invasion of malignant gliomas and implications for therapeutic treatment |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5979613/ https://www.ncbi.nlm.nih.gov/pubmed/29642503 http://dx.doi.org/10.3390/ijms19041115 |
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