Mutual Destruction of Deep Lung Tumor Tissues by Nanodrug‐Conjugated Stealth Mesenchymal Stem Cells

Lung cancer is a highly malignant tumor, and targeted delivery of anti‐cancer drugs to deep lung tumor tissue remains a challenge in drug design. Here, it is demonstrated that bone marrow mesenchymal stem cells armed with nanodrugs are highly targeted and mutually destructive with malignant lung can...

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Detalles Bibliográficos
Autores principales: Kim, Sang‐Woo, Lee, Yeon Kyung, Hong, Jeong Hee, Park, Jun‐Young, Choi, Young‐Ae, Lee, Dong Un, Choi, Jungil, Sym, Sun Jin, Kim, Sang‐Hyun, Khang, Dongwoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5979625/
https://www.ncbi.nlm.nih.gov/pubmed/29876212
http://dx.doi.org/10.1002/advs.201700860
Descripción
Sumario:Lung cancer is a highly malignant tumor, and targeted delivery of anti‐cancer drugs to deep lung tumor tissue remains a challenge in drug design. Here, it is demonstrated that bone marrow mesenchymal stem cells armed with nanodrugs are highly targeted and mutually destructive with malignant lung cancer cells and successfully eradicate lung tumors tissues. Using this approach, the current clinical dose of anti‐cancer drugs for the treatment of malignant lung tumors can be decreased by more than 100‐fold without triggering immunotoxicity.

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