Mutual Destruction of Deep Lung Tumor Tissues by Nanodrug‐Conjugated Stealth Mesenchymal Stem Cells

Lung cancer is a highly malignant tumor, and targeted delivery of anti‐cancer drugs to deep lung tumor tissue remains a challenge in drug design. Here, it is demonstrated that bone marrow mesenchymal stem cells armed with nanodrugs are highly targeted and mutually destructive with malignant lung can...

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Autores principales: Kim, Sang‐Woo, Lee, Yeon Kyung, Hong, Jeong Hee, Park, Jun‐Young, Choi, Young‐Ae, Lee, Dong Un, Choi, Jungil, Sym, Sun Jin, Kim, Sang‐Hyun, Khang, Dongwoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5979625/
https://www.ncbi.nlm.nih.gov/pubmed/29876212
http://dx.doi.org/10.1002/advs.201700860
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author Kim, Sang‐Woo
Lee, Yeon Kyung
Hong, Jeong Hee
Park, Jun‐Young
Choi, Young‐Ae
Lee, Dong Un
Choi, Jungil
Sym, Sun Jin
Kim, Sang‐Hyun
Khang, Dongwoo
author_facet Kim, Sang‐Woo
Lee, Yeon Kyung
Hong, Jeong Hee
Park, Jun‐Young
Choi, Young‐Ae
Lee, Dong Un
Choi, Jungil
Sym, Sun Jin
Kim, Sang‐Hyun
Khang, Dongwoo
author_sort Kim, Sang‐Woo
collection PubMed
description Lung cancer is a highly malignant tumor, and targeted delivery of anti‐cancer drugs to deep lung tumor tissue remains a challenge in drug design. Here, it is demonstrated that bone marrow mesenchymal stem cells armed with nanodrugs are highly targeted and mutually destructive with malignant lung cancer cells and successfully eradicate lung tumors tissues. Using this approach, the current clinical dose of anti‐cancer drugs for the treatment of malignant lung tumors can be decreased by more than 100‐fold without triggering immunotoxicity.
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spelling pubmed-59796252018-06-06 Mutual Destruction of Deep Lung Tumor Tissues by Nanodrug‐Conjugated Stealth Mesenchymal Stem Cells Kim, Sang‐Woo Lee, Yeon Kyung Hong, Jeong Hee Park, Jun‐Young Choi, Young‐Ae Lee, Dong Un Choi, Jungil Sym, Sun Jin Kim, Sang‐Hyun Khang, Dongwoo Adv Sci (Weinh) Full Papers Lung cancer is a highly malignant tumor, and targeted delivery of anti‐cancer drugs to deep lung tumor tissue remains a challenge in drug design. Here, it is demonstrated that bone marrow mesenchymal stem cells armed with nanodrugs are highly targeted and mutually destructive with malignant lung cancer cells and successfully eradicate lung tumors tissues. Using this approach, the current clinical dose of anti‐cancer drugs for the treatment of malignant lung tumors can be decreased by more than 100‐fold without triggering immunotoxicity. John Wiley and Sons Inc. 2018-02-26 /pmc/articles/PMC5979625/ /pubmed/29876212 http://dx.doi.org/10.1002/advs.201700860 Text en © 2018 The Authors. Published by WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Full Papers
Kim, Sang‐Woo
Lee, Yeon Kyung
Hong, Jeong Hee
Park, Jun‐Young
Choi, Young‐Ae
Lee, Dong Un
Choi, Jungil
Sym, Sun Jin
Kim, Sang‐Hyun
Khang, Dongwoo
Mutual Destruction of Deep Lung Tumor Tissues by Nanodrug‐Conjugated Stealth Mesenchymal Stem Cells
title Mutual Destruction of Deep Lung Tumor Tissues by Nanodrug‐Conjugated Stealth Mesenchymal Stem Cells
title_full Mutual Destruction of Deep Lung Tumor Tissues by Nanodrug‐Conjugated Stealth Mesenchymal Stem Cells
title_fullStr Mutual Destruction of Deep Lung Tumor Tissues by Nanodrug‐Conjugated Stealth Mesenchymal Stem Cells
title_full_unstemmed Mutual Destruction of Deep Lung Tumor Tissues by Nanodrug‐Conjugated Stealth Mesenchymal Stem Cells
title_short Mutual Destruction of Deep Lung Tumor Tissues by Nanodrug‐Conjugated Stealth Mesenchymal Stem Cells
title_sort mutual destruction of deep lung tumor tissues by nanodrug‐conjugated stealth mesenchymal stem cells
topic Full Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5979625/
https://www.ncbi.nlm.nih.gov/pubmed/29876212
http://dx.doi.org/10.1002/advs.201700860
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