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Evolutionary rescue in a host–pathogen system results in coexistence not clearance

The evolutionary rescue of host populations may prevent extinction from novel pathogens. However, the conditions that facilitate rapid evolution of hosts, in particular the population variation in host susceptibility, and the effects of host evolution in response to pathogens on population outcomes...

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Detalles Bibliográficos
Autores principales: Christie, Mark Redpath, Searle, Catherine Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5979755/
https://www.ncbi.nlm.nih.gov/pubmed/29875810
http://dx.doi.org/10.1111/eva.12568
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author Christie, Mark Redpath
Searle, Catherine Laura
author_facet Christie, Mark Redpath
Searle, Catherine Laura
author_sort Christie, Mark Redpath
collection PubMed
description The evolutionary rescue of host populations may prevent extinction from novel pathogens. However, the conditions that facilitate rapid evolution of hosts, in particular the population variation in host susceptibility, and the effects of host evolution in response to pathogens on population outcomes remain largely unknown. We constructed an individual‐based model to determine the relationships between genetic variation in host susceptibility and population persistence in an amphibian‐fungal pathogen (Batrachochytrium dendrobatidis) system. We found that host populations can rapidly evolve reduced susceptibility to a novel pathogen and that this rapid evolution led to a 71‐fold increase in the likelihood of host–pathogen coexistence. However, the increased rates of coexistence came at a cost to host populations; fewer populations cleared infection, population sizes were depressed, and neutral genetic diversity was lost. Larger adult host population sizes and greater adaptive genetic variation prior to the onset of pathogen introduction led to substantially reduced rates of extinction, suggesting that populations with these characteristics should be prioritized for conservation when species are threatened by novel infectious diseases.
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spelling pubmed-59797552018-06-06 Evolutionary rescue in a host–pathogen system results in coexistence not clearance Christie, Mark Redpath Searle, Catherine Laura Evol Appl Original Articles The evolutionary rescue of host populations may prevent extinction from novel pathogens. However, the conditions that facilitate rapid evolution of hosts, in particular the population variation in host susceptibility, and the effects of host evolution in response to pathogens on population outcomes remain largely unknown. We constructed an individual‐based model to determine the relationships between genetic variation in host susceptibility and population persistence in an amphibian‐fungal pathogen (Batrachochytrium dendrobatidis) system. We found that host populations can rapidly evolve reduced susceptibility to a novel pathogen and that this rapid evolution led to a 71‐fold increase in the likelihood of host–pathogen coexistence. However, the increased rates of coexistence came at a cost to host populations; fewer populations cleared infection, population sizes were depressed, and neutral genetic diversity was lost. Larger adult host population sizes and greater adaptive genetic variation prior to the onset of pathogen introduction led to substantially reduced rates of extinction, suggesting that populations with these characteristics should be prioritized for conservation when species are threatened by novel infectious diseases. John Wiley and Sons Inc. 2017-11-20 /pmc/articles/PMC5979755/ /pubmed/29875810 http://dx.doi.org/10.1111/eva.12568 Text en © 2017 The Authors. Evolutionary Applications published by John Wiley & Sons Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Christie, Mark Redpath
Searle, Catherine Laura
Evolutionary rescue in a host–pathogen system results in coexistence not clearance
title Evolutionary rescue in a host–pathogen system results in coexistence not clearance
title_full Evolutionary rescue in a host–pathogen system results in coexistence not clearance
title_fullStr Evolutionary rescue in a host–pathogen system results in coexistence not clearance
title_full_unstemmed Evolutionary rescue in a host–pathogen system results in coexistence not clearance
title_short Evolutionary rescue in a host–pathogen system results in coexistence not clearance
title_sort evolutionary rescue in a host–pathogen system results in coexistence not clearance
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5979755/
https://www.ncbi.nlm.nih.gov/pubmed/29875810
http://dx.doi.org/10.1111/eva.12568
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