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Higher High-Sensitivity C Reactive Protein is Associated with Future Premature Ventricular Contraction: a Community Based Prospective Cohort Study

We aimed to determine whether hs-CRP is a predictor of future premature ventricular contraction (PVC) events in a community based population. A total of 101,510 participants were recruited at baseline (2006–2007). The follow-up visits were conducted every two years. Participants who were free from P...

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Autores principales: Chen, Yue, Wu, Shouling, Li, Wenyu, Wang, Binhao, Han, Xu, Yang, Yiheng, Guan, Xumin, Yu, Haixu, Khalid, Bin Waleed, Li, Huihua, Xia, Yunlong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5979945/
https://www.ncbi.nlm.nih.gov/pubmed/29581482
http://dx.doi.org/10.1038/s41598-018-22868-8
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author Chen, Yue
Wu, Shouling
Li, Wenyu
Wang, Binhao
Han, Xu
Yang, Yiheng
Guan, Xumin
Yu, Haixu
Khalid, Bin Waleed
Li, Huihua
Xia, Yunlong
author_facet Chen, Yue
Wu, Shouling
Li, Wenyu
Wang, Binhao
Han, Xu
Yang, Yiheng
Guan, Xumin
Yu, Haixu
Khalid, Bin Waleed
Li, Huihua
Xia, Yunlong
author_sort Chen, Yue
collection PubMed
description We aimed to determine whether hs-CRP is a predictor of future premature ventricular contraction (PVC) events in a community based population. A total of 101,510 participants were recruited at baseline (2006–2007). The follow-up visits were conducted every two years. Participants who were free from PVC at baseline and achieved the fourth visit, or diagnosed of PVC during the subsequent visits were included for analyses. Diagnosis of PVC was based on standard supine resting, 10-s 12-lead ECG. Cox regression was applied to evaluate the association between quartiles of hs-CRP and the incidence of PVCs. 60710 participants (male: 79.9%, mean age 49.4 years) were included for analyses. During a mean follow-up of 74.9 ± 7.4 months, 908 (1.5%) participants were diagnosed with PVC. Participants of the highest quartile of hs-CRP had significantly increased risk of PVC events as compared with the lowest quartile (HR 1.36; 95% CI 1.12–1.66); and stratified analyses showed similar result in males (HR 1.45; 95% CI 1.16–1.80), but not in females (HR 1.12; 95% CI 0.71–1.79). Moreover, elevated serum hs-CRP was associated with future PVC in participants without history of myocardial infarction or stroke (HR 1.34; 95% CI 1.09–1.65). Elevated hs-CRP was an independent predictor of PVC in Chinese population, especially in men.
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spelling pubmed-59799452018-06-06 Higher High-Sensitivity C Reactive Protein is Associated with Future Premature Ventricular Contraction: a Community Based Prospective Cohort Study Chen, Yue Wu, Shouling Li, Wenyu Wang, Binhao Han, Xu Yang, Yiheng Guan, Xumin Yu, Haixu Khalid, Bin Waleed Li, Huihua Xia, Yunlong Sci Rep Article We aimed to determine whether hs-CRP is a predictor of future premature ventricular contraction (PVC) events in a community based population. A total of 101,510 participants were recruited at baseline (2006–2007). The follow-up visits were conducted every two years. Participants who were free from PVC at baseline and achieved the fourth visit, or diagnosed of PVC during the subsequent visits were included for analyses. Diagnosis of PVC was based on standard supine resting, 10-s 12-lead ECG. Cox regression was applied to evaluate the association between quartiles of hs-CRP and the incidence of PVCs. 60710 participants (male: 79.9%, mean age 49.4 years) were included for analyses. During a mean follow-up of 74.9 ± 7.4 months, 908 (1.5%) participants were diagnosed with PVC. Participants of the highest quartile of hs-CRP had significantly increased risk of PVC events as compared with the lowest quartile (HR 1.36; 95% CI 1.12–1.66); and stratified analyses showed similar result in males (HR 1.45; 95% CI 1.16–1.80), but not in females (HR 1.12; 95% CI 0.71–1.79). Moreover, elevated serum hs-CRP was associated with future PVC in participants without history of myocardial infarction or stroke (HR 1.34; 95% CI 1.09–1.65). Elevated hs-CRP was an independent predictor of PVC in Chinese population, especially in men. Nature Publishing Group UK 2018-03-26 /pmc/articles/PMC5979945/ /pubmed/29581482 http://dx.doi.org/10.1038/s41598-018-22868-8 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Chen, Yue
Wu, Shouling
Li, Wenyu
Wang, Binhao
Han, Xu
Yang, Yiheng
Guan, Xumin
Yu, Haixu
Khalid, Bin Waleed
Li, Huihua
Xia, Yunlong
Higher High-Sensitivity C Reactive Protein is Associated with Future Premature Ventricular Contraction: a Community Based Prospective Cohort Study
title Higher High-Sensitivity C Reactive Protein is Associated with Future Premature Ventricular Contraction: a Community Based Prospective Cohort Study
title_full Higher High-Sensitivity C Reactive Protein is Associated with Future Premature Ventricular Contraction: a Community Based Prospective Cohort Study
title_fullStr Higher High-Sensitivity C Reactive Protein is Associated with Future Premature Ventricular Contraction: a Community Based Prospective Cohort Study
title_full_unstemmed Higher High-Sensitivity C Reactive Protein is Associated with Future Premature Ventricular Contraction: a Community Based Prospective Cohort Study
title_short Higher High-Sensitivity C Reactive Protein is Associated with Future Premature Ventricular Contraction: a Community Based Prospective Cohort Study
title_sort higher high-sensitivity c reactive protein is associated with future premature ventricular contraction: a community based prospective cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5979945/
https://www.ncbi.nlm.nih.gov/pubmed/29581482
http://dx.doi.org/10.1038/s41598-018-22868-8
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