Modeling the effects of lipid peroxidation during ferroptosis on membrane properties

Ferroptosis is a form of regulated cell death characterized by the accumulation of lipid hydroperoxides. There has been significant research on the pathways leading to the accumulation of oxidized lipids, but the downstream effects and how lipid peroxides cause cell death during ferroptosis remain a...

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Autores principales: Agmon, Eran, Solon, Jérôme, Bassereau, Patricia, Stockwell, Brent R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5979948/
https://www.ncbi.nlm.nih.gov/pubmed/29581451
http://dx.doi.org/10.1038/s41598-018-23408-0
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author Agmon, Eran
Solon, Jérôme
Bassereau, Patricia
Stockwell, Brent R.
author_facet Agmon, Eran
Solon, Jérôme
Bassereau, Patricia
Stockwell, Brent R.
author_sort Agmon, Eran
collection PubMed
description Ferroptosis is a form of regulated cell death characterized by the accumulation of lipid hydroperoxides. There has been significant research on the pathways leading to the accumulation of oxidized lipids, but the downstream effects and how lipid peroxides cause cell death during ferroptosis remain a major puzzle. We evaluated key features of ferroptosis in newly developed molecular dynamics models of lipid membranes to investigate the biophysical consequences of lipid peroxidation, and generated hypotheses about how lipid peroxides contribute to cell death during ferroptosis.
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spelling pubmed-59799482018-06-06 Modeling the effects of lipid peroxidation during ferroptosis on membrane properties Agmon, Eran Solon, Jérôme Bassereau, Patricia Stockwell, Brent R. Sci Rep Article Ferroptosis is a form of regulated cell death characterized by the accumulation of lipid hydroperoxides. There has been significant research on the pathways leading to the accumulation of oxidized lipids, but the downstream effects and how lipid peroxides cause cell death during ferroptosis remain a major puzzle. We evaluated key features of ferroptosis in newly developed molecular dynamics models of lipid membranes to investigate the biophysical consequences of lipid peroxidation, and generated hypotheses about how lipid peroxides contribute to cell death during ferroptosis. Nature Publishing Group UK 2018-03-26 /pmc/articles/PMC5979948/ /pubmed/29581451 http://dx.doi.org/10.1038/s41598-018-23408-0 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Agmon, Eran
Solon, Jérôme
Bassereau, Patricia
Stockwell, Brent R.
Modeling the effects of lipid peroxidation during ferroptosis on membrane properties
title Modeling the effects of lipid peroxidation during ferroptosis on membrane properties
title_full Modeling the effects of lipid peroxidation during ferroptosis on membrane properties
title_fullStr Modeling the effects of lipid peroxidation during ferroptosis on membrane properties
title_full_unstemmed Modeling the effects of lipid peroxidation during ferroptosis on membrane properties
title_short Modeling the effects of lipid peroxidation during ferroptosis on membrane properties
title_sort modeling the effects of lipid peroxidation during ferroptosis on membrane properties
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5979948/
https://www.ncbi.nlm.nih.gov/pubmed/29581451
http://dx.doi.org/10.1038/s41598-018-23408-0
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