Cargando…

Passively Driven Probe Based on Miniaturized Propeller for Intravascular Optical Coherence Tomography

Optical coherent tomography (OCT) has enabled clinical applications ranging from ophthalmology to cardiology that revolutionized in vivo medical diagnostics in the last few decades, and a variety of endoscopic probes have been developed in order to meet the needs of various endoscopic OCT imaging. W...

Descripción completa

Detalles Bibliográficos
Autores principales: Lu, Yu, Li, Zhongliang, Nan, Nan, Bu, Yang, Liu, Xuebo, Xu, Xiangdong, Wang, Xuan, Sasaki, Osami, Wang, Xiangzhao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980104/
https://www.ncbi.nlm.nih.gov/pubmed/29581592
http://dx.doi.org/10.1038/s41598-018-23547-4
_version_ 1783327830857220096
author Lu, Yu
Li, Zhongliang
Nan, Nan
Bu, Yang
Liu, Xuebo
Xu, Xiangdong
Wang, Xuan
Sasaki, Osami
Wang, Xiangzhao
author_facet Lu, Yu
Li, Zhongliang
Nan, Nan
Bu, Yang
Liu, Xuebo
Xu, Xiangdong
Wang, Xuan
Sasaki, Osami
Wang, Xiangzhao
author_sort Lu, Yu
collection PubMed
description Optical coherent tomography (OCT) has enabled clinical applications ranging from ophthalmology to cardiology that revolutionized in vivo medical diagnostics in the last few decades, and a variety of endoscopic probes have been developed in order to meet the needs of various endoscopic OCT imaging. We propose a passive driven intravascular optical coherent tomography (IV-OCT) probe in this paper. Instead of using any electrically driven scanning device, the probe makes use of the kinetic energy of the fluid that flushes away the blood during the intravascular optical coherence tomography imaging. The probe converts it into the rotational kinetic energy of the propeller, and the rotation of the rectangular prism mounted on the propeller shaft enables the scanning of the beam. The probe is low cost, and enables unobstructed stable circumferential scanning over 360 deg. The experimental results show that the probe scanning speed can exceed 100 rotations per second (rps). Spectral-domain OCT imaging of a phantom and porcine cardiac artery are demonstrated with axial resolution of 13.6 μm, lateral resolution of 22 μm, and sensitivity of 101.7 dB. We present technically the passively driven IV-OCT probe in full detail and discuss how to optimize the probe in further.
format Online
Article
Text
id pubmed-5980104
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-59801042018-06-06 Passively Driven Probe Based on Miniaturized Propeller for Intravascular Optical Coherence Tomography Lu, Yu Li, Zhongliang Nan, Nan Bu, Yang Liu, Xuebo Xu, Xiangdong Wang, Xuan Sasaki, Osami Wang, Xiangzhao Sci Rep Article Optical coherent tomography (OCT) has enabled clinical applications ranging from ophthalmology to cardiology that revolutionized in vivo medical diagnostics in the last few decades, and a variety of endoscopic probes have been developed in order to meet the needs of various endoscopic OCT imaging. We propose a passive driven intravascular optical coherent tomography (IV-OCT) probe in this paper. Instead of using any electrically driven scanning device, the probe makes use of the kinetic energy of the fluid that flushes away the blood during the intravascular optical coherence tomography imaging. The probe converts it into the rotational kinetic energy of the propeller, and the rotation of the rectangular prism mounted on the propeller shaft enables the scanning of the beam. The probe is low cost, and enables unobstructed stable circumferential scanning over 360 deg. The experimental results show that the probe scanning speed can exceed 100 rotations per second (rps). Spectral-domain OCT imaging of a phantom and porcine cardiac artery are demonstrated with axial resolution of 13.6 μm, lateral resolution of 22 μm, and sensitivity of 101.7 dB. We present technically the passively driven IV-OCT probe in full detail and discuss how to optimize the probe in further. Nature Publishing Group UK 2018-03-26 /pmc/articles/PMC5980104/ /pubmed/29581592 http://dx.doi.org/10.1038/s41598-018-23547-4 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Lu, Yu
Li, Zhongliang
Nan, Nan
Bu, Yang
Liu, Xuebo
Xu, Xiangdong
Wang, Xuan
Sasaki, Osami
Wang, Xiangzhao
Passively Driven Probe Based on Miniaturized Propeller for Intravascular Optical Coherence Tomography
title Passively Driven Probe Based on Miniaturized Propeller for Intravascular Optical Coherence Tomography
title_full Passively Driven Probe Based on Miniaturized Propeller for Intravascular Optical Coherence Tomography
title_fullStr Passively Driven Probe Based on Miniaturized Propeller for Intravascular Optical Coherence Tomography
title_full_unstemmed Passively Driven Probe Based on Miniaturized Propeller for Intravascular Optical Coherence Tomography
title_short Passively Driven Probe Based on Miniaturized Propeller for Intravascular Optical Coherence Tomography
title_sort passively driven probe based on miniaturized propeller for intravascular optical coherence tomography
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980104/
https://www.ncbi.nlm.nih.gov/pubmed/29581592
http://dx.doi.org/10.1038/s41598-018-23547-4
work_keys_str_mv AT luyu passivelydrivenprobebasedonminiaturizedpropellerforintravascularopticalcoherencetomography
AT lizhongliang passivelydrivenprobebasedonminiaturizedpropellerforintravascularopticalcoherencetomography
AT nannan passivelydrivenprobebasedonminiaturizedpropellerforintravascularopticalcoherencetomography
AT buyang passivelydrivenprobebasedonminiaturizedpropellerforintravascularopticalcoherencetomography
AT liuxuebo passivelydrivenprobebasedonminiaturizedpropellerforintravascularopticalcoherencetomography
AT xuxiangdong passivelydrivenprobebasedonminiaturizedpropellerforintravascularopticalcoherencetomography
AT wangxuan passivelydrivenprobebasedonminiaturizedpropellerforintravascularopticalcoherencetomography
AT sasakiosami passivelydrivenprobebasedonminiaturizedpropellerforintravascularopticalcoherencetomography
AT wangxiangzhao passivelydrivenprobebasedonminiaturizedpropellerforintravascularopticalcoherencetomography