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Antibody response to Influenza booster vaccination in Franches‐Montagnes stallions supplemented with Equi‐Strath(®): a randomized trial

Bio‐Strath(®) is a plasmolyzed yeast product enriched with herbs, malt, honey and orange juice. In this study, the effect of Equi‐Strath(®), the adapted product for horses, on the equine immune system was evaluated. A routine influenza booster vaccination was used as a model to study the effects of...

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Autores principales: van Dorland, Hendrika A., Zanoni, Reto, Gerber, Vinzenz, Jeannerat, Elise, Wiederkehr, Danja, Burger, Dominik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980167/
https://www.ncbi.nlm.nih.gov/pubmed/29851307
http://dx.doi.org/10.1002/vms3.95
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author van Dorland, Hendrika A.
Zanoni, Reto
Gerber, Vinzenz
Jeannerat, Elise
Wiederkehr, Danja
Burger, Dominik
author_facet van Dorland, Hendrika A.
Zanoni, Reto
Gerber, Vinzenz
Jeannerat, Elise
Wiederkehr, Danja
Burger, Dominik
author_sort van Dorland, Hendrika A.
collection PubMed
description Bio‐Strath(®) is a plasmolyzed yeast product enriched with herbs, malt, honey and orange juice. In this study, the effect of Equi‐Strath(®), the adapted product for horses, on the equine immune system was evaluated. A routine influenza booster vaccination was used as a model to study the effects of Equi‐Strath(®) supplementation on the immune response. Twenty healthy Franches‐Montagnes stallions with pre‐existing antibody levels were randomly divided into a study group (SG, n = 10) receiving 0.06 mL/kg bodyweight of Equi‐Strath(®), and a control group (CG, n = 10), receiving the same amount of placebo, daily. The supplement and placebo were given from week 1 until week 14 of the trial. After 10 weeks, the horses were vaccinated with a commercial vaccine containing equine influenza strains of the H3N8 subtype. Antibody titres in blood were measured at day 0 before vaccination, and 14 and 32 days after vaccination. In addition, a complete blood count (CBC) was performed on day 0 and day 32. A linear increase of haemagglutination inhibition titres in both groups was observed after vaccination, but with no difference between treatment groups. CBC components remained unaffected by treatment. In conclusion, daily Equi‐Strath(®) supplementation did not affect the adaptive immune response in stallions after a routine commercial H3N8 influenza booster vaccination.
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spelling pubmed-59801672018-06-06 Antibody response to Influenza booster vaccination in Franches‐Montagnes stallions supplemented with Equi‐Strath(®): a randomized trial van Dorland, Hendrika A. Zanoni, Reto Gerber, Vinzenz Jeannerat, Elise Wiederkehr, Danja Burger, Dominik Vet Med Sci Original Articles Bio‐Strath(®) is a plasmolyzed yeast product enriched with herbs, malt, honey and orange juice. In this study, the effect of Equi‐Strath(®), the adapted product for horses, on the equine immune system was evaluated. A routine influenza booster vaccination was used as a model to study the effects of Equi‐Strath(®) supplementation on the immune response. Twenty healthy Franches‐Montagnes stallions with pre‐existing antibody levels were randomly divided into a study group (SG, n = 10) receiving 0.06 mL/kg bodyweight of Equi‐Strath(®), and a control group (CG, n = 10), receiving the same amount of placebo, daily. The supplement and placebo were given from week 1 until week 14 of the trial. After 10 weeks, the horses were vaccinated with a commercial vaccine containing equine influenza strains of the H3N8 subtype. Antibody titres in blood were measured at day 0 before vaccination, and 14 and 32 days after vaccination. In addition, a complete blood count (CBC) was performed on day 0 and day 32. A linear increase of haemagglutination inhibition titres in both groups was observed after vaccination, but with no difference between treatment groups. CBC components remained unaffected by treatment. In conclusion, daily Equi‐Strath(®) supplementation did not affect the adaptive immune response in stallions after a routine commercial H3N8 influenza booster vaccination. John Wiley and Sons Inc. 2018-02-27 /pmc/articles/PMC5980167/ /pubmed/29851307 http://dx.doi.org/10.1002/vms3.95 Text en © 2018 The Authors. Veterinary Medicine and Science Published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
van Dorland, Hendrika A.
Zanoni, Reto
Gerber, Vinzenz
Jeannerat, Elise
Wiederkehr, Danja
Burger, Dominik
Antibody response to Influenza booster vaccination in Franches‐Montagnes stallions supplemented with Equi‐Strath(®): a randomized trial
title Antibody response to Influenza booster vaccination in Franches‐Montagnes stallions supplemented with Equi‐Strath(®): a randomized trial
title_full Antibody response to Influenza booster vaccination in Franches‐Montagnes stallions supplemented with Equi‐Strath(®): a randomized trial
title_fullStr Antibody response to Influenza booster vaccination in Franches‐Montagnes stallions supplemented with Equi‐Strath(®): a randomized trial
title_full_unstemmed Antibody response to Influenza booster vaccination in Franches‐Montagnes stallions supplemented with Equi‐Strath(®): a randomized trial
title_short Antibody response to Influenza booster vaccination in Franches‐Montagnes stallions supplemented with Equi‐Strath(®): a randomized trial
title_sort antibody response to influenza booster vaccination in franches‐montagnes stallions supplemented with equi‐strath(®): a randomized trial
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980167/
https://www.ncbi.nlm.nih.gov/pubmed/29851307
http://dx.doi.org/10.1002/vms3.95
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