Smad7 deficiency decreases iron and haemoglobin through hepcidin up‐regulation by multilayer compensatory mechanisms

To maintain iron homoeostasis, the iron regulatory hormone hepcidin is tightly controlled by BMP‐Smad signalling pathway, but the physiological role of Smad7 in hepcidin regulation remains elusive. We generated and characterized hepatocyte‐specific Smad7 knockout mice (Smad7 (Alb/Alb)), which showed...

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Detalles Bibliográficos
Autores principales: An, Peng, Wang, Hao, Wu, Qian, Wang, Jiaming, Xia, Zhidan, He, Xuyan, Wang, Xinhui, Chen, Yan, Min, Junxia, Wang, Fudi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980186/
https://www.ncbi.nlm.nih.gov/pubmed/29575577
http://dx.doi.org/10.1111/jcmm.13546

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980186/
https://www.ncbi.nlm.nih.gov/pubmed/29575577
http://dx.doi.org/10.1111/jcmm.13546

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