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Oxygen‐Evolving Mesoporous Organosilica Coated Prussian Blue Nanoplatform for Highly Efficient Photodynamic Therapy of Tumors
Oxygen (O(2)) plays a critical role during photodynamic therapy (PDT), however, hypoxia is quite common in most solid tumors, which limits the PDT efficacy and promotes the tumor aggression. Here, a safe and multifunctional oxygen‐evolving nanoplatform is costructured to overcome this problem. It is...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980201/ https://www.ncbi.nlm.nih.gov/pubmed/29876209 http://dx.doi.org/10.1002/advs.201700847 |
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author | Yang, Zhen Lu Tian, Wei Wang, Qing Zhao, Ying Zhang, Yun Lei Tian, Ying Tang, Yu Xia Wang, Shou Ju Liu, Ying Ni, Qian Qian Lu, Guang Ming Teng, Zhao Gang Zhang, Long Jiang |
author_facet | Yang, Zhen Lu Tian, Wei Wang, Qing Zhao, Ying Zhang, Yun Lei Tian, Ying Tang, Yu Xia Wang, Shou Ju Liu, Ying Ni, Qian Qian Lu, Guang Ming Teng, Zhao Gang Zhang, Long Jiang |
author_sort | Yang, Zhen Lu |
collection | PubMed |
description | Oxygen (O(2)) plays a critical role during photodynamic therapy (PDT), however, hypoxia is quite common in most solid tumors, which limits the PDT efficacy and promotes the tumor aggression. Here, a safe and multifunctional oxygen‐evolving nanoplatform is costructured to overcome this problem. It is composed of a prussian blue (PB) core and chlorin e6 (Ce6) anchored periodic mesoporous organosilica (PMO) shell (denoted as PB@PMO‐Ce6). In the highly integrated nanoplatform, the PB with catalase‐like activity can catalyze hydrogen peroxide to generate O(2), and the Ce6 transform the O(2) to generate more reactive oxygen species (ROS) upon laser irradiation for PDT. This PB@PMO‐Ce6 nanoplatform presents well‐defined core–shell structure, uniform diameter (105 ± 12 nm), and high biocompatibility. This study confirms that the PB@PMO‐Ce6 nanoplatform can generate more ROS to enhance PDT than free Ce6 in cellular level (p < 0.001). In vivo, the singlet oxygen sensor green staining, tumor volume of tumor‐bearing mice, and histopathological analysis demonstrate that this oxygen‐evolving nanoplatform can elevate singlet oxygen to effectively inhibit tumor growth without obvious damage to major organs. The preliminary results from this study indicate the potential of biocompatible PB@PMO‐Ce6 nanoplatform to elevate O(2) and ROS for improving PDT efficacy. |
format | Online Article Text |
id | pubmed-5980201 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-59802012018-06-06 Oxygen‐Evolving Mesoporous Organosilica Coated Prussian Blue Nanoplatform for Highly Efficient Photodynamic Therapy of Tumors Yang, Zhen Lu Tian, Wei Wang, Qing Zhao, Ying Zhang, Yun Lei Tian, Ying Tang, Yu Xia Wang, Shou Ju Liu, Ying Ni, Qian Qian Lu, Guang Ming Teng, Zhao Gang Zhang, Long Jiang Adv Sci (Weinh) Full Papers Oxygen (O(2)) plays a critical role during photodynamic therapy (PDT), however, hypoxia is quite common in most solid tumors, which limits the PDT efficacy and promotes the tumor aggression. Here, a safe and multifunctional oxygen‐evolving nanoplatform is costructured to overcome this problem. It is composed of a prussian blue (PB) core and chlorin e6 (Ce6) anchored periodic mesoporous organosilica (PMO) shell (denoted as PB@PMO‐Ce6). In the highly integrated nanoplatform, the PB with catalase‐like activity can catalyze hydrogen peroxide to generate O(2), and the Ce6 transform the O(2) to generate more reactive oxygen species (ROS) upon laser irradiation for PDT. This PB@PMO‐Ce6 nanoplatform presents well‐defined core–shell structure, uniform diameter (105 ± 12 nm), and high biocompatibility. This study confirms that the PB@PMO‐Ce6 nanoplatform can generate more ROS to enhance PDT than free Ce6 in cellular level (p < 0.001). In vivo, the singlet oxygen sensor green staining, tumor volume of tumor‐bearing mice, and histopathological analysis demonstrate that this oxygen‐evolving nanoplatform can elevate singlet oxygen to effectively inhibit tumor growth without obvious damage to major organs. The preliminary results from this study indicate the potential of biocompatible PB@PMO‐Ce6 nanoplatform to elevate O(2) and ROS for improving PDT efficacy. John Wiley and Sons Inc. 2018-02-22 /pmc/articles/PMC5980201/ /pubmed/29876209 http://dx.doi.org/10.1002/advs.201700847 Text en © 2018 The Authors. Published by WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Full Papers Yang, Zhen Lu Tian, Wei Wang, Qing Zhao, Ying Zhang, Yun Lei Tian, Ying Tang, Yu Xia Wang, Shou Ju Liu, Ying Ni, Qian Qian Lu, Guang Ming Teng, Zhao Gang Zhang, Long Jiang Oxygen‐Evolving Mesoporous Organosilica Coated Prussian Blue Nanoplatform for Highly Efficient Photodynamic Therapy of Tumors |
title | Oxygen‐Evolving Mesoporous Organosilica Coated Prussian Blue Nanoplatform for Highly Efficient Photodynamic Therapy of Tumors |
title_full | Oxygen‐Evolving Mesoporous Organosilica Coated Prussian Blue Nanoplatform for Highly Efficient Photodynamic Therapy of Tumors |
title_fullStr | Oxygen‐Evolving Mesoporous Organosilica Coated Prussian Blue Nanoplatform for Highly Efficient Photodynamic Therapy of Tumors |
title_full_unstemmed | Oxygen‐Evolving Mesoporous Organosilica Coated Prussian Blue Nanoplatform for Highly Efficient Photodynamic Therapy of Tumors |
title_short | Oxygen‐Evolving Mesoporous Organosilica Coated Prussian Blue Nanoplatform for Highly Efficient Photodynamic Therapy of Tumors |
title_sort | oxygen‐evolving mesoporous organosilica coated prussian blue nanoplatform for highly efficient photodynamic therapy of tumors |
topic | Full Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980201/ https://www.ncbi.nlm.nih.gov/pubmed/29876209 http://dx.doi.org/10.1002/advs.201700847 |
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