GI‐530159, a novel, selective, mechanosensitive two‐pore‐domain potassium (K(2P)) channel opener, reduces rat dorsal root ganglion neuron excitability

BACKGROUND AND PURPOSE: TREK two‐pore‐domain potassium (K(2P)) channels play a critical role in regulating the excitability of somatosensory nociceptive neurons and are important mediators of pain perception. An understanding of the roles of TREK channels in pain perception and, indeed, in other pat...

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Detalles Bibliográficos
Autores principales: Loucif, Alexandre J C, Saintot, Pierre‐Philippe, Liu, Jia, Antonio, Brett M, Zellmer, Shannon G, Yoger, Katrina, Veale, Emma L, Wilbrey, Anna, Omoto, Kiyoyuki, Cao, Lishuang, Gutteridge, Alex, Castle, Neil A, Stevens, Edward B, Mathie, Alistair
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Themed Section: Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980259/
https://www.ncbi.nlm.nih.gov/pubmed/29150838
http://dx.doi.org/10.1111/bph.14098

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